Are KIR genes associated with clinical parameters in the course of periodontitis?
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Introduction: Periodontitis is a common chronic inflammatory disease. It seems that natural killer (NK) cells play a role in the pathogenesis of periodontitis. KIRs are a family of inhibitory or activating receptors expressed on the surfaces of NK cells and some subpopulations of T lymphocytes. The aim of this study was to evaluate the impact of KIR genes on the pocket depth (PD) and clinical attachment loss (CAL) parameter values as markers of disease clinical course.Materials and methods: The patients in the study were submitted to anamnesis and to clinical and periodontal examination. The subjects (400) were categorized into two groups: periodontitis (250 including 100 with moderate and 140 with severe periodontitis) and controls (150). Both groups were divided into two subgroups: KIR gene positive (presence of KIR gene in the genome) and KIR gene negative (lack of the KIR gene in the genome).Results: The mean value for CAL was more than 5 mm, and the mean value for PD was more than 4 mm in the periodontitis group. The ANOVA test performed for the control group showed that neither PD nor CAL parameters differed between particular KIR-positive and KIR-negative healthy individuals. Similar results were obtained for all subgroups of chronic periodontitis patients and periodontitis patients (moderate as well as severe): no association between KIR genes and PD or CAL parameters was found.Discussions: The activated immune system is important in pathogenesis of periodontal disease. On the other hand, tissue damage as a response to infection could be due to activation mediated by KIR. In our study no association between either KIR genes presence or absence and PD and CAL parameters was found. Nevertheless, the impact of KIR genes on the clinical course of periodontal disease requires further investigations.
Authors and Affiliations
Małgorzata Mazurek-Mochol, Edyta Majorczyk, Jadwiga Banach, Elżbieta Dembowska, Andrzej Pawlik, Piotr Kuśnierczyk
Keywords
Related Articles
- EP ID EP67485
- DOI -
- Views 120
- Downloads 0
Proteins in cancer multidrug resistance
Multidrug Resistance (MDR) is defined as insensitivity to administered medicines that are structurally unrelated and have different molecular targets. Cancers possess numerous mechanisms of drug resistance, involving var...
Stwardnienie rozsiane – etiopatogeneza i możliwości diagnostyczne
Stwardnienie rozsiane (multiple sclerosis, MS) jest przewlekłą, zapalno-demielinizacyjną chorobą o podłożu immunologicznym, w powstawaniu której biorą udział czynniki egzogenne, środowiskowe oraz genetyczne. Charakteryzu...
Adropina - rola fizjologiczna i patofizjologiczna
Działanie cytotoksyczne onkonazy w skojarzeniu z lekami schematu R-CHOP na komórki linii chłoniaka rozlanego z dużych komórek B (DLBCL)
Usefulness of estimation of blood procalcitonin concentration versus C-reactive protein concentration and white blood cell count for therapeutic monitoring of sepsis in neonates
Aim: This study was intended to assess the clinical usefulness of blood procalcitonin (PCT) concentrations for the diagnosis and therapeutic monitoring of nosocomial neonatal sepsis.Material/Methods: The enrolment criter...