ARE THE CLINICAL FINDINGS DIFFERENT IN PATIENTS WITH FAMILIAL BREAST AND OVARIAN CANCER SYNDROME WHO UNDERWENT PROPHYLACTIC SALPINGO-OOPHORECTOMY ?
Journal Title: Kocatepe Medical Journal - Year 2023, Vol 24, Issue 1
Abstract
OBJECTIVE: The aim of this study was comparison of demographic and medical characteristics among BRCA1 and BRCA2 gene mutation carriers in women who underwent prophylactic surgery (bilateral salpingo-oophorectomy; BSO)due to BRCA1/2 (breast cancer1/2) gene mutation. MATERIAL AND METHODS: Twenty-four women who were found to have BRCA1/2 gene mutations in our clinic in the last 5 years and had undergone prophylactic surgery (BSO) were included in the study. Patients with BRCA1 and BRCA2 gene mutations were compared in terms of age, number of pregnancies and births, body mass index (BMI), Ca125 value, history of infertility and breast cancer, type of surgery and postoperative pathology results. RESULTS: The mean age of the patients included in the study was 45.5±5.8, BMI was 27.6±5.4kg/m2, Ca125 value was 17.9±14.1IU/ml, and 79.2% of the patients had a history of breast cancer. A total of 62.5% patients had BRCA1 and 37.5% had BRCA2 gene mutations. There was no statistically difference found between the two groups in terms of age, number of pregnancies and births, BMI, Ca125 value, history of infertility and breast cancer, type of surgery and postoperative pathology (p>0.05). As a result of the postoperative pathological evaluation, ovarian cancer was detected in one patient (in the BRCA1 group). CONCLUSIONS: There is no difference in terms of demographic and medical characteristics between patients with BRCA1 and BRCA2 gene mutations, and it should be kept in mind that malignancy may be found as a result of the final pathology.
Authors and Affiliations
Gökşen GÖRGÜLÜ, Muzaffer SANCI
Keywords
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- EP ID EP722162
- DOI https://doi.org/10.18229/kocatepetip.991496
- Views 38
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