Arginase: An Emerging Key Player in Periodontal Disease and Diabetes Mellitus.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Introduction: Arginase is a semi-essential amino acid, an enzyme found in saliva which is involved in inflammation.Arginase is found mainly in the human liver, also found in salivary glands. Saliva is an important biological material containing local and systemic derived markers. Analysis of arginase may be used as a diagnostic aid to evaluate the periodontal status and to clearly understand the pathogenic process of periodontal disease. Aims And Objectives: To evaluate arginase levels in healthy, gingivitis, chronic periodontitis, and chronic periodontitis subjects with diabetes mellitus and to compare it with clinical parameters. Methodology: Total of 100 patients, divided into 25 healthy subjects, 25 gingivitis subjects, 25 chronic periodontitis subjects(CP), 25 chronic periodontitis (CP) subjects with Type2 Diabetes mellitus (Ty2DM). Duly signed informed consent was obtained from all the subjects and saliva samples were collected. Arginase activity was measured by UV spectrophotometry at 515nm. Result: Arginase level in CP subjects and CP subjects with Ty2DM are significantly higher than subjects with healthy and gingivitis. Conclusion: Early evaluation of periodontal status is essential to prevent the progression of the disease. Salivary arginase levels can be used as a reliable marker in periodontal disease also can be regarded as a novel marker for the vascular complications of diabetes.
Authors and Affiliations
Dr. Nagaraj B. Kalburgi
Keywords
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