Aripiprazole tablets: Development and Validation of a Dissolution Methodology
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 10
Abstract
The aim of this work was to develop and validated a dissolution methodology for aripiprazole tablets by spectrophotometry on ultraviolet light (UV). The dissolution mediums tested were 0.1 M HCl, pH 4.5– citrate buffer and pH 6.8–phosphate buffer, and it was also tested the influence of apparatus and rotation speed. After an UV scan spectrum from 400 to 200 nm to determinate the maximum wavelength absorbance, samples were analyzed by UV visible spectrophotometric method. The selected parameters were 0.1 M HCl as dissolution medium, using paddles as apparatus at rotation speed of 50 rpm, with UV analysis at 249 nm. The method was validated per ICH guidelines, and the results showed that the dissolution methodology for aripiprazole tablets with 0.1 M HCl as dissolution medium, using paddles as apparatus at 50 rpm, with analysis at wavelength of 249 nm, with sampling points at 5, 10, 15, 30, 45 and 60 minutes is specific, linear, precise and accurate and could be applied for quality control of aripiprazole tablets, since there is no official monograph.
Authors and Affiliations
Khaoanny de Souza, Tiago Rafael Sausen
Keywords
Related Articles
- EP ID EP406520
- DOI -
- Views 136
- Downloads 0
Comparing Residual Integration Levels of Some IntegrationDeficient Lentiviral Vectors
Lentiviral vectors (LVs) have many advantageous characteristics making them a good choice in the field of gene therapy. Nevertheless, their integration may lead to detrimental effects. To overcome this problem, lentivira...
Immobilization and Death of Bacteria by Flora Seal® Microbial Sealant
A new advantage of cyanoacrylate surgicalmicrobial sealant, i.e. FloraSeal®, is that organisms dieshortly upon contact providing additional protection to the patient.
Analyzing the Flexibility of Pharmaceutical and Biopharmaceutical Facility Options
.
A Study on The Applications of Silver Nanoparticle Synthesized Using The Aqueous Extract And The Purified Secondary Metabolites of Lichen Parmelia perlata
Lichens are generally a symbiotic association between a fungal and an algal partner. They produce an array of secondary metabolites that are common in plants or higher fungi but 80% of metabolites are produced specifical...
Antibacterial and Insecticidal Activity of Crude Seed Extracts of Annona squamosa L.
The present investigation was conducted to evaluate the antibacterial and Insecticidal efficiency of traditional plant Annonas quamosa. Seeds extract of plant Annonas quamosa were prepared by methanol extraction method a...