Aromataze inhibitors in the treatment of breast cancer
Journal Title: OncoReview - Year 2012, Vol 2, Issue 3
Abstract
The main goal for hormonal therapy of breast cancer is to inhibit action of endogenous estrogens to breast cancer cells. Discovery of hormonal receptors and knowledge of their biological role employment to manner hormonal treatment as target therapy. Postmenopausal estrogens are synthesized from androgens, mainly androstenedione, which is converted into estrone. Aromatase inhibitors potently inhibit aromatase activity and also suppress estrogen levels in plasma and tissue. Aromatase inhibitor are safety and convenient drugs In clinical studies in postmenopausal women with breast cancer shown superior to tamoxifen for the treatment of metastatic disease, and in neoadjuvant approach Studies of adjuvant therapy with aromatase inhibitors include: head-to-head studies of the aromatase inhibitor versus tamoxifen monotherapy, sequential therapy of 2–3 years of tamoxifen followed by an aromatase inhibitor (or the opposite sequence) versus 5 years of tamoxifen monotherapy: extended therapy with an aromatase inhibitor after 5 years of tamoxifen. Aromatase inhibitors are active and are recommended in every stage of breast cancer.
Authors and Affiliations
Tadeusz Pieńkowski
Keywords
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