Aromatic C-acylation of Phenols by using Acid and Acid Anhydride in Presence of Lewis Acid Catalyst
Journal Title: American Journal of PharmTech Research - Year 2018, Vol 8, Issue 0
Abstract
Ring acylations of aromatic substances are very difficult to achieve to a great extent. Nencki reaction has attempted on mono to poly hydroxy and substituted phenols have good results. Reactions are using solely acetic acid, acetic anhydride and adipic acid or mixture of acid and anhydride resulting complete consumption of phenols. The use Lewis acid freshly fused ZnCl2 is best suitable catalyst compare to others. The essential data on phenols acylation has been studied and described as below.
Authors and Affiliations
Mahendra Sawant
Keywords
Related Articles
- EP ID EP619771
- DOI 10.21276/ajptr.2018.08.05.12
- Views 155
- Downloads 0
Stability Indicating UPLC Method Development and Validation for Simultaneous Determination of Ertugliflozin and Sitagliptin
A selective, robust, economic and short method was developed for the simultaneous estimation of the Ertugliflozin (EGZ) and Sitagliptin (SGP) in Tablet dosage form. Chromatogram was run through X-bridge c18 50 x 2.1 mm,...
Gold Nano Particles of Cancer Treatment: A Review
Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitise. Cancer is the disease caused by an uncontrolled...
Evaluation of Anxiolytic Activity Methanolic Extract of Caltropis Gigantea Flowers
The present study was undertaken to evaluate Anxiolytic activity of methanolic extract of caltropis gigantea flowers. Of caltropis gigantea (200,400 mg/kg) was studied. Diazepam used as a standard drug (2mg/kg), by using...
Microparticle as Suitable Drug Carriers For Colon Targeting – A Recent Review
In the recent year colonic drug delivery has gained importance for delivery of drug for the treatment of local diseases associated with colon and systemic delivery of therapeutic peptides and proteins. Treatment could be...
Aromatic C-acylation of Phenols by using Acid and Acid Anhydride in Presence of Lewis Acid Catalyst
Ring acylations of aromatic substances are very difficult to achieve to a great extent. Nencki reaction has attempted on mono to poly hydroxy and substituted phenols have good results. Reactions are using solely acetic a...