Arsenic- Exposure, Mechanism of Action and Toxicity Analysis: A Prenatal View
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 7
Abstract
Arsenic continues to poison the drinking water of thousands across the globe. Numerous studies have evaluated the carcinogenic potential of lifetime exposure and also the ill effects of prenatal exposure. Population Studies have revealed the strong correlation between the development of skin, bladder, kidney and lung cancer and arsenic exposure in endemic areas. Although the adult exposure outcomes continue to be evaluated, the prenatal exposure aspect is neglected in most studies. Our study aims to explore the co carcinogenic effect of prenatal arsenic exposure. Most experiments conducted so far in this topic utilizes models of adult exposure and very few studies have reported association of prenatal exposure to any type of carcinogenesis. This study will address the underlying mechanisms behind this association. The knowledge derived from the study can be used to develop or design early life detection markers for in utero arsenic exposure and the anomalies that may ensue.
Authors and Affiliations
Shagun Shukla
Keywords
Related Articles
- EP ID EP526945
- DOI -
- Views 67
- Downloads 0
Diagnostic Efficacy of ERG and CK5 Coexpression in Prostatic Intraepithelial Neoplasia and Carcinoma
Background: Prostate lesions either benign, Premalignant or malignant, continues to be distressing and annoying problem for old people from centuries. Carcinoma of prostate is most common internal malignancy among men &...
Is High Intensity exercise Training Among Type II Diabetic Mellitus a Boon in Diabetic Care?
Introduction: Diabetes mellitus type II forms major among non communicable diseases worldwide causing greater disability and impact on economy of individual and society physical activities, particularly hi intensity exer...
Optimal parameters for Gene Xpert MTB/RIF and LAM Strip determine Test for Diagnosis of Tuberculosis using urine from HIV patients at Moi Teaching and Referral Hospital, Kenya
The application of Gene Xpert MTB/RIF® assay for testing non-sputum clinical samples in Western Kenya has not been reported. We are reporting on use of Zn, CD4 count, Hb, Creatinine, Proteinuria, and Hematuria as optimal...
Lateral Pinning for Supracondylar Humerus Fracture in Children: Does The Entry Point of the Pins have an Influence on the Outcome of the Fracture Fixation?
Introduction: Closed reduction with percutaneous pin fixation remains mainstay treatment for displaced supracondylar fractures. Because of documented iatrogenic ulnar nerve injury from medial pin, predilection for placem...
Bile Duct Injuries Following Laparoscopic Cholecystectomy and their Outcome
Introduction: Bile duct injuries are still among the most common and dreadful complications, following laparoscopic cholecystectomies despite advancement of training and technology. Methods: Prospective study of bile duc...