ASSAM BORA RICE STARCH AS DIRECTLY COMPRESSIBLE FILLERBINDER
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
Introduction: North-east India, including Assam, is recognized as a centre of origin of rice and is endowed with exceptionally rich rice diversity. Assam Bora rice (Oryza sativa L, Japonica variety), a group of glutinous rice of Assam has been reported to contain up to 90% starch. With increasing demand and search for natural starches with desirable properties for use in the pharmaceutical industries, the present work evaluates the possible use of Assam Bora rice starch as directly compressible tablet excipient. Methods: The starch was extracted from the rice and the powder characteristics were evaluated. Various parameters studied, include, particle size, true density, bulk density, tapped density and flow characteristics. Tablets containing Ketotifen Fumarate as a model drug were prepared with Assam Bora rice starch as unique filler-binder. Results and conclusion: The tablets were evaluated for tensile strength, friability, drug content, disintegration and dissolution profiles. The tablet properties show that Assam Bora rice starch is a useful product for preparation of tablets by direct compression.
Authors and Affiliations
P. Rajak
Keywords
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