Assesment of serum lipid in nephrotic syndrome in children
Journal Title: International Journal of Medical and Health Research - Year 2017, Vol 3, Issue 3
Abstract
Hyperlipidemia is a common finding in nephrotic syndrome. There is increased total Cholesterol, LDL, VLDL and low or normal HDL. Hyperlipidemia is usually observed during the active phase of disease and disappears with resolution of proteinuria. But in relapsing cases, it may persist and may increase risk of atherosclerosis in later life. Hence serial monitoring of lipids is required to predict prognosis. Hence, our study is an attempt to know derangement of serum lipids in nephrotic syndrome. Methods: A prospective study included 30 children with nephrotic syndrome, aged between 0-12 years. They were clinically examined and lipid profile was done in each case before steroid therapy, after one month of therapy and at the end of therapy.10 children without liver and kidney disorders were taken as controls. Results: In all cases, there were increased mean total cholesterol, LDl, VLDL and triglyceride. However there was no significant change in HDL. With steroid treatment, in first episode nephrotic syndrome, there was highly significant reduction in the mean levels of pretreatment total cholesterol, LDL (p= 0.001) and triglycerides (p= 0.016). However in relapse nephrotic syndrome, even at end of treatment, serum lipids were found to be persistently high. Conclusion: Our study concludes that, there is generalized hyperlipidemia (except HDL) and hypoalbuminemia. The serum cholesterol level in first episode nephrotic syndrome reaches normal at the end of steroid therapy. But in cases of relapse, there is persistent elevation in the cholesterol levels, which may predispose to development of atherosclerosis and progression to chronic renal failure.
Authors and Affiliations
Dr. Nassem Ahmad, Dr. Dinesh Kumar Rajak
Keywords
Related Articles
- EP ID EP583367
- DOI -
- Views 169
- Downloads 0
Estimation of serum prolactin in children admitted with seizure disorders
Most cases of seizure occur as the result of central nervous system infection, brain injury, stroke, brain tumors, and birth defects, through a process known as epileptogenesis. The etiology in many cases of seizure diso...
Evaluation of the percentage of proximal caries diagnosis in Bitewing radiography technique by senior students of Sari dental school in 2018
Background and Purpose: dental caries is the most common chronic disease in the world and the rate of dental caries in many developing countries, it is considered as a health problem. Radiography is one of the best diagn...
Assessment of different parameters for discharge against medical advice at neonatal intensive care unit
The studies in paediatric populations indicated that the problem of discharge against medical advice (DAMA) is more prevalent in neonates. This has serious consequences considering limited physiological reserve of the ne...
Original research article: Correlation between insulin resistance (by HOMA-IR) and lipid profile among obese adults
Background: Obesity is a major growing global health problem of recent times. It is a leading preventable cause of death worldwide, with increasing rates in adults and children. Obesity, diabetes and hyperlipidaemia have...
Borderline class III patient and treatment options: A comprehensive review
Treatment planning in orthodontics plays a key role in determining the successful treatment of any kind of malocclusion. Skeletal class III malocclusions are generally difficult to treat because of the complex nature of...