Assessing the Neurocognitive function effects of ketamine in Cardiac Surgical patients
Journal Title: International Journal of Clinical Anesthesia and Research - Year 2018, Vol 2, Issue 1
Abstract
Background: Despite remarkable progress in surgical, cardiopulmonary bypass (CPB) and anesthetic tecniques, neurocognitive damage still remains an important cause of postoperative morbidity in cardiac surgery. The aetiology of neurocognitive damage is likely to be multifocal; including macro and microemboli, cerebral hypoperfusion, inflammation and nonpulsatile flow. N-methyl-D-asparticAcid (NMDA) receptors play an important role during neurocognitive damage. Ketamine is a non-competitive antagonist to the phencyclidine site of NMDA receptor for glutamate and directly suppresses proinflammatory cytokine production. The aim of the present study was to evaluate whether ketamine has neuroprotective effects during open-heart surgery through the use of neurocognitive tests.
Authors and Affiliations
Demet Dogan Erol
Keywords
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- EP ID EP559839
- DOI 10.29328/journal.ijcar.1001007
- Views 70
- Downloads 0
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