Assessment of Ageing-Dependent Effects on Sperm Functions following Semen Cryopreservation
Journal Title: Veterinary Medicine – Open Journal - Year 2017, Vol 2, Issue 2
Abstract
There has been an increased improvement in the cryopreservation protocol of semen, which contributes to the preservation of genetic resources.1,2 Cryo-induced damage to spermatozoa is attributed to membrane deterioration caused mainly by the formation of intracellular ice and increased oxidative stress, resulting in a loss of the sperm fertilizing ability.3 It is noteworthy that ageing-dependent processes in frozen-thawed semen occur in different sperm compartments, and are associated with membrane modifications of specific lipid-protein interactions, activation of an apoptosis-like mechanism and reduced genomic integrity, which consequently compromise sperm cryo-survival.4,5 Moreover, ageing is a natural process occurring in sperm cells during semen preservation, and there is no single sperm test that can effectively predict the fertilizing capacity of semen following the different reproductive technologies.6
Authors and Affiliations
Leyland Fraser
Keywords
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- EP ID EP545199
- DOI 10.17140/VMOJ-2-e005
- Views 179
- Downloads 0
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