ASSESSMENT OF ANTIDIABETIC ACTIVITY OF THE TRADITIONAL INDIAN AYURVEDIC FORMULATION BRAHMI GRITHAM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: The aim of the present study was to determine the antidiabetic activity of Brahmi gritham a traditional Indian ayurvedic formulation in streptozotocin-induced diabetes in rats.Methods: Diabetes was induced by a single intra-peritoneal injection of streptozotocin (55mg/kg body weight) in the experimental animals. The anti-hyperglycaemic potential of Brahmi gritham (500 mg/kg body weight) was studied by estimating the levels of plasma blood glucose and the levels of serum total cholesterol, triglycerides, total protein and albumin in the experimental rats. The serum renal functional (creatinine; urea; uric acid) and liver functional markers (aspartate transaminase; alanine transaminase; alkaline phosphatase) were also measured. The tested parameters were compared with those of the normal and the standard drug glibenclamide-treated rats. Histological analysis of the liver was done in order to visualize the efficacy of Brahmi gritham in preventing changes in liver histology in diabetic rats.Results: Brahmi gritham showed significant (p<0.05) reduction in the elevated levels of plasma glucose, serum liver and renal function markers and total cholesterol. The formulation was also effective in restoring normal total protein and albumin levels in the serum of experimental rats.Conclusion: The study revealed significant antidiabetic potential of Brahmi gritham in the experimental rats indicating its role in the effective management of diabetes.Â
Authors and Affiliations
Evan Prince Sabina, Udhaya Lavinya Baskaran, Sherry Joseph Martin, Monisha Swaminathan, Yashodhara Bhattacharya, Shreni Tandon
Keywords
Related Articles
- EP ID EP579318
- DOI -
- Views 71
- Downloads 0
PUNARNAVA-A NATURAL REMEDY BY AYURVEDA
This review aims to provide comprehensive affirmations on the phytochemical and pharmacological aspects of Boerhaavia Diffusa, Nyctaginaceae also known as “Punarnavaâ€. It possesses a vast ethnomedical history and rep...
METHANOLIC EXTRACT OF BACOPA MONNIERA REDUCE DEVELOPMENT OF TOLERANCE TO ANTIEPILEPTIC EFFECT OF PHENOBARBITONE IN MICE
Objective: Side effects and development of tolerance to antiepileptic drugs necessitate identifying alterative and improved approaches to treat epilepsy. Bacopa monniera (BM), is a natural product which is used to treat...
PRESCRIPTION PATTERN AND COST OF ILLNESS (COI) OF INFLAMMATORY BOWEL DISEASE (IBD) IN A TERTIARY CARE HOSPITAL
Objective: Treatment of Inflammatory Bowel disease (IBD) centers on agents used to relieve inflammatory process. None of the drugs used for IBD are curative; at best they serve to control the disease process. The potenti...
A CASE SERIES ON ANTI NMDAR ENCEPHALITIS
N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune neurological disorder arising from the generation of antibodies which binds to the synaptic proteins. Here we present a case series of 3 cases where the...
NEUROPROTECTIVE ACTIVITY OF NOVEL CUR-CA-THIONE AND ITS OXIDATIVE STRESS STUDY
Objective: Alzheimer’s disease a progressive neurodegenerative disorder affected by the formation of amyloid beta and tau proteins. Medicinal plants have been proved significantly for its anti-oxidant and anti-inflamma...