Assessment of Antihyperglycemic Potential of Lyophilized and Oven-Dried Extract of Calocybe indica in Experimentally Streptozotocin-Nicotinamide Induced Diabetic Rats
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 4
Abstract
Uncontrolled diabetes can cause a number complication including heart disease, stroke, liver and kidney damage. Presently herbal formulations are mostly recommended to control diabetes due to lesser side effects compared to synthetic drug. Calocybe indica is rich in protein, flavonoids, lipid, fiber, carbohydrate and vitamin and incorporates an ample amount of essential amino acid and low fat product. The present study was aimed to evaluate the antihyperglycemic activity of lyophilized and oven-dried extract of Calocybe indica against STZ-induced diabetic complications as hepatotoxicity and nephropathy. The lyophilized extract (LE) and oven-dried extracts (ODE) of Calocybe indica were administered orally in Streptozotocin (STZ)-induced diabetic rats. After the administration of fractions, blood glucose levels were monitored at specific intervals and it was found that they were significant lowered. The effect of extracts on induced hyperlipidemia was evaluated and found significantly lowered the elevated total cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) level while increased the high density lipoprotein (HDL). The increased level of aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH), urea and creatinine in serum of diabetic rats were observed, and significantly decreased on administration of lyophilized and oven-dried extract of Calocybe indica. The results imply that extract could have a protective effect against hepatic and renal damage induced by oxidative stress in the diabetic rats. The lyophilized extract of Calocybe indica produces higher protective effect compared to oven-dried extract.
Authors and Affiliations
Roy Amit | Columbia Institute of Pharmacy, Tekari, Raipur (CG), India, Prasad Pushpa| Columbia Institute of Pharmacy, Tekari, Raipur (CG), India, Corresponding Email: pushpaprasad81@gmail.com
Keywords
Related Articles
- EP ID EP11643
- DOI -
- Views 235
- Downloads 9
Potential Effect of 2% Chlorhexidine Gel in the Implant Screw Hole on Bacterial Count
Background: Microbial penetration inside the implant’s internal hole creates a bacterial reservoir that is related with an area of inflamed connective tissue opposite the fxture-abutment junction and this can affect...
A STUDY TO ASSESS INJECTION PRACTICES IN CIVIL DISPENSARIES
Background: About 16 billion injections are administered each year worldwide, and at least half of them are unsafe. India contributes 25-30% of the global injection load. A majority of curative injections are unnecessar...
HEMOGLOBIN A1C INDUCED DOWN-REGULATION OF CD36 OF PLASMODIUM FALCIPARUM PARASITIZED RED CELL
Objective: High values of glycosylated hemoglobin have been found to correlate with decreased deformability of erythrocyte. CD36 (Cluster of Differentiation 36) is an integral membrane protein found on the surface of ma...
The Role of Marital Burnout and Early Maladaptive Schemas in Marital Satisfaction between Young Couples
Given the fundamental role of the family structure and the importance of proper marriages in modern society as well as the important role of childhood and its effect on marital relations in adulthood, this study aimed t...
Sphenoid Sinus Anatomical Relations and their Implications in Endoscopic Sinus Surgery
With advances in endoscopic sinus surgery (ESS), radiologist and otolaryngologists should have thorough knowledge of anatomy of paranasal sinus (PNS). Regarding this, sphenoid sinuses are the most variable among paranas...