Assessment of Blood Glutathione Peroxidase and Glutathione Reductase in Glioma Patients of Gwalior Chambal region, Pre and Post Radiotherapy
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 6
Abstract
Radiation therapy has been used in cancer treatment for many decades; it is used to eradicate cancer and as a palliative to relieve pain associated with metastases. In the course of treatment, radiation produces numerous biological perturbations in cells such as free radical generation. Exposure to ionization radiation inherent tissue sensitivity and repair, and modulating intracellular factors that include oxygen concentration, and level of antioxidants in the tissue environment. The brain has high content of peroxidizable unsaturated fatty acids, which is a key in lipid peroxidation and a shortage of antioxidant defense systems or more generation of ROS, or free radicals, can exceed the scavenging ability of endogenous antioxidants, resulting in a shift of the redox state of the brain to the oxidative state. Gliomas are the most common intra-axial tumors arising from the central nervous system. The effect of radiation on the antioxidant enzyme GPx and GR in glioma patients of Gwalior Chambal region has been presented in this work. Several studies implicated the association of dysfunctional GPx and GR and cancer risk and in our work we have also find highly significant decrease in the levels of GPx and GR in the haemolysate of glioma patients pre and post radiotherapy which postulates lack of antioxidant defence system and radiation somehow making it more inefficient.
Authors and Affiliations
Akshay Nigam
Keywords
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