Assessment of Blood Glutathione Peroxidase and Glutathione Reductase in Glioma Patients of Gwalior Chambal region, Pre and Post Radiotherapy
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 6
Abstract
Radiation therapy has been used in cancer treatment for many decades; it is used to eradicate cancer and as a palliative to relieve pain associated with metastases. In the course of treatment, radiation produces numerous biological perturbations in cells such as free radical generation. Exposure to ionization radiation inherent tissue sensitivity and repair, and modulating intracellular factors that include oxygen concentration, and level of antioxidants in the tissue environment. The brain has high content of peroxidizable unsaturated fatty acids, which is a key in lipid peroxidation and a shortage of antioxidant defense systems or more generation of ROS, or free radicals, can exceed the scavenging ability of endogenous antioxidants, resulting in a shift of the redox state of the brain to the oxidative state. Gliomas are the most common intra-axial tumors arising from the central nervous system. The effect of radiation on the antioxidant enzyme GPx and GR in glioma patients of Gwalior Chambal region has been presented in this work. Several studies implicated the association of dysfunctional GPx and GR and cancer risk and in our work we have also find highly significant decrease in the levels of GPx and GR in the haemolysate of glioma patients pre and post radiotherapy which postulates lack of antioxidant defence system and radiation somehow making it more inefficient.
Authors and Affiliations
Akshay Nigam
Keywords
Related Articles
- EP ID EP211674
- DOI -
- Views 91
- Downloads 0
Choice of Oral Contraception among Urban Women in Eastern India: A Prospective Observational Study
Background: The use of contraceptive has been recognised as a key element in reducing fertility and control of population, which in turn is important for the development of the nation. Family planning means achieving the...
Effects of Adding Clonidine to Bupivacaine for Caudal Analgesia in children
Caudal epidural analgesia with bupivacaine is very popular in paediatric anaesthesia for providing intra and postoperative analgesia. Several adjuvants have been used to prolong the action of caudal bupivacaine. We evalu...
Normal Vs Low Serum Level Vitamin D in Patient with Symptomatic Early RA Disease Activity
The aim of this study to show the relation of low vs normal serum vitamin D 25(OH)D (vit D) level in the patient with early onset RA to disease activity. METHODS: 92 RA Patients (72 female and 20 male) with recent-onset...
Normative Data for Upper Limb Nerve Conduction Study in North India
Introduction: Nerve conduction study assesses peripheral motor and sensory functions by recording the evoked response to electrical stimulation of peripheral nerves. Nerve conduction studies have become a simple and reli...
Early and Late Complications Following Surgery for Rectal Carcinoma: Study of 56 Cases
INTRODUCTION: Colorectal carcinoma is the most common gastrointestinal malignancy. Mainstay of treatment is surgical excision. Surgical procedures include anterior resection (AR) with or without diversion colostomy (DC),...