Assessment of Blood Glutathione Peroxidase and Glutathione Reductase in Glioma Patients of Gwalior Chambal region, Pre and Post Radiotherapy

Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 6

Abstract

Radiation therapy has been used in cancer treatment for many decades; it is used to eradicate cancer and as a palliative to relieve pain associated with metastases. In the course of treatment, radiation produces numerous biological perturbations in cells such as free radical generation. Exposure to ionization radiation inherent tissue sensitivity and repair, and modulating intracellular factors that include oxygen concentration, and level of antioxidants in the tissue environment. The brain has high content of peroxidizable unsaturated fatty acids, which is a key in lipid peroxidation and a shortage of antioxidant defense systems or more generation of ROS, or free radicals, can exceed the scavenging ability of endogenous antioxidants, resulting in a shift of the redox state of the brain to the oxidative state. Gliomas are the most common intra-axial tumors arising from the central nervous system. The effect of radiation on the antioxidant enzyme GPx and GR in glioma patients of Gwalior Chambal region has been presented in this work. Several studies implicated the association of dysfunctional GPx and GR and cancer risk and in our work we have also find highly significant decrease in the levels of GPx and GR in the haemolysate of glioma patients pre and post radiotherapy which postulates lack of antioxidant defence system and radiation somehow making it more inefficient.

Authors and Affiliations

Akshay Nigam

Keywords

Related Articles

Assessment of Risk Factors Associated with Coronary Artery Diseases in a Study Population- A Clinical Study

Background: Coronary artery disease (CAD) is one of the most common causes of mortality and morbidity in general population in both developed and developing countries. It is a leading cause of death in India. The present...

HPLC based evaluation of Haemoglobinopathies in a tertiary care setting in North Kerala

Introduction- Inherited Haemoglobin disorders are the most common single gene disorders in the world with the highest prevalence in regions where malaria was endemic. The burden of this disorder is of such a magnitude th...

Hepatitis B Virus Vaccination Status and Knowledge about Hepetitis B Infection among Health Care Workers of Katihar Medical College, Bihar

Background: Hepatitis B (HB) is a global Public Health Problem infecting nearly 2 billion people around the globe. Health care workers are at risk of acquiring HBV, HCV, and HIV infections via exposure to patient’s blood...

Scrotal Emergencies-Two case reports on Scrotal Exploration Scenario

This case report evaluates the management of acute scrotal emergency in two similar cases with presenting complaints and different outcomes post-scrotal exploration. One case of young male discusses the eventual outcome...

Open Reduction of Supracondylar Fracture – Revisited

Supracondylar fracture of humerus .is a common injury of elbow among children. When a satisfactory reduction can't be obtain by closed method, management remains controversial. The choice is then to accept an imperfect r...

Download PDF file
  • EP ID EP211674
  • DOI -
  • Views 83
  • Downloads 0

How To Cite

Akshay Nigam (2015). Assessment of Blood Glutathione Peroxidase and Glutathione Reductase in Glioma Patients of Gwalior Chambal region, Pre and Post Radiotherapy. Journal of Medical Science And clinical Research, 3(6), 6205-6211. https://europub.co.uk/articles/-A-211674