Assessment of Chromium Oxide Nanoparticles Intake in Rattus norvegicus by Primary Renal Function Markers and RBC Architecture
Journal Title: Global Journal of Zoology - Year 2017, Vol 2, Issue 1
Abstract
Haematological tests are signifi cant diagnostic tools that are equally valuable as indicators of toxic insult or stress due to xenobiotics and environmental fl uctuations. Present study was designed to investigate alterations in primary renal function markers, pathological changes in kidneys and variations in RBCs shape of male wistar rats due to chromium oxide nanoparticles (Cr2O3NPs) exposure. Cr2O3NPs are transition metal oxide NPs which are widely being used as catalysts, pigments and coating materials. Therefore, toxicological evaluation is fundamental with respect to their increasing applications. In the current study, synthesis of Cr2O3 NPs was accomplished by sol - gel method and characterized in sequential manner by electron microscopy (TEM and SEM). TEM analysis revealed size - distribution of test NPs in the range 22.50 ± 1.76 nm. SEM represented the morphological features with high homogeneity of sample NPs validating Cr2O3NPs synthesis. Toxicological fi ndings revealed deviations in renal function test of treated rats with respect to the control group indicative of kidney damage. Blood Urea Nitrogen (BUN) was found to be signifi cantly higher (p < 0.05) after 14 days high dose exposure in comparison to control rats. Extensive changes in kidneys architecture were noted after repeated exposures to high dose. Various structural deformations of RBCs including tear drop cells, bite cells, elliptocytes, echinocytes etc were also observed. Results of present investigations, though preliminary but clearly demonstrate that oral administration of Cr2O3 NPs induces biochemical changes consequently leading to alterations in renal function parameters and RBC shapes of exposed rats.
Authors and Affiliations
Ahmad Riaz, Fatima Ravish
Promising role of Carob (Ceratonia siliqua L) phytochemical components against neurotoxicity induced by monosodium glutamate
The phytochemical constituents of Carob (Ceratonia siliqua L) showed therapeutic medical importance especially concerning neurotoxicity which represents the major public health problem. Neurodegenerative disorders are de...
Faunistic analysis of mosquitoes (Diptera, Culicidae) in Teruel Province (Northeastern Spain)
Intensive samplings for mosquito larvae were conducted between June and October 2014 in the main representative wetlands of the Teruel province (Northeastern Spain). All water bodies listed in the Inventory of Protected...
Chromatin Remodeling Complexes: The Regulators of Genome Function
Genome in eukaryotes is large enough to be accommodated in tiny nucleus. It is required to achieve high degree of compaction for getting into the nucleus. Compaction is achieved by folding the DNA in the form of chromati...
Babesia Microti – Known and Unknown Protists
B. microti is known as the main etiological agent of human babesiosis and there are some case studies for that disease, highlighting the fact that this is an important “emerging tick-borne disease”. However a lot of info...
Laboratory Evaluation of Certain Essential Oils for Their Larvicidal Activity against Aedes Albopictus, Vector of Dengue and Chikungunya
Mosquito borne diseases including malaria, fi lariasis, dengue, chikungunya and various forms of encephalitis impose enormous menace to human as well as animals. These diseases cause large number of mortality and morbidi...