Assessment of coagulation parameters in malaria infected pregnant women in Imo state Nigeria.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 9
Abstract
A cross-sectional prospective study was carried out on malaria infected pregnant women attending FMC Owerri , Imo state, Nigeria with the aim of assessing coagulation parameters, A total of 300 subjects within the age range of 18-45 years:100 infected pregnant women , 100 non- infected pregnant women and 100 non-infected non pregnant women (were recruited) for this study. Blood samples were collected from the subjects using standard method. These were analysed for coagulations parameters using semi- automated coagulation machine and ELISA respectively. Also malaria parasite infection was screened using rapid test kit (Bio) and confirmed microscopically. In addition, questionnaires were administered to the subjects to elicit demographic information about the consequences of malaria infection. The ages of the participants were analysed using percentages. All statistical analysis was performed using statistical package SAS version 9.4.The results were expressed as mean ± standard error of mean. Two tailed ANOVA and student t-test were used for comparison of differences in various groups and the level of significant was set at P<0.05.Pearson correlation was used for test of association of the various groups. The various results were represented graphically using overlay plot, box plot and correlation matrix to show nature of association. The data showed the mean age of the participant 29± 5.2 (40%), followed by 31-35 age range (26%). Most of the participants (78%) were in the third trimester at the time of study, while 14 and 8 were in the second and first trimester respectively. About three quarter of the participants (46%) were self employed, (16.7%) were civil servants and establishment, while the rest were workers in private, traders, students and unemployed. Plasmodium falciparum was the only specie identified. The partial prothrombin time with kaolin (PTTK) was significantly increased compared with the malaria pregnant women and non malaria pregnant women (P<0.05).. Protein C and Protein S were remarkably decreased in infected malaria subjects compared to non-infected subjects. Protein C and S are the major anticoagulants and inflammatory markers in malaria infection, thereby ameliorating thrombosis in pregnancy.
Authors and Affiliations
Okorie, H. M. 1, 2 , Obeagu, E. I. 3 Eze, E.N.2 and Jeremaiah, Z.A.2
Keywords
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- EP ID EP551710
- DOI 10.22192/ijcrms.2018.04.09.006
- Views 131
- Downloads 0
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