Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast Cancer
Journal Title: Middle East Journal of Cancer - Year 2019, Vol 10, Issue 1
Abstract
Background: Cancer antigen 15-3 and carcinoembryonic antigen are used in clinical and laboratory diagnosis of metastatic breast cancer. Previous studies have noted conflicting results about the association between carcinoembryonic antigen and cancer antigen 15-3 in metastatic breast cancer. The present study examined serum tumor marker levels of carcinoembryonic antigen and cancer antigen 15-3 among patients with different subtypes of metastatic breast cancer. Methods: In this cross-sectional study, we assessed metastatic breast cancer patients diagnosed between 2005 and 2012 who referred to academic Hospitals affiliated with Mashhad University of Medical Sciences. The patients were selected by systematic randomization sampling. Demographic, clinical, pathological, and therapeutic data were collected from patients’ hospital records. Statistical analyses were performed by Statistical Package for the Social Sciences version 16.0 software. Results: A total of 298 eligible patients enrolled in the study. Patients’ median age was 48.39±12.57 years. Elevated serum levels of carcinoembryonic antigen were identified in 65.17% of patients and cancer antigen 15-3 in 57.29% of patients. Based on molecular subtype categorization, 109 (39.5%) patients were human epidermal growth factor receptor 2 negative and 105 (38.0%) patients were in the luminal group. There was no significant correlation between serum carcinoembryonic antigen and cancer antigen 15-3 with subtypes of the tumor. The most common sites for metastasis were bones and liver, respectively. However, there was no significant correlation between serum carcinoembryonic antigen and cancer antigen 15-3 with the site of metastasis. There was a significant association between serum carcinoembryonic antigen level and stages IIA and IV. Conclusion: One of the most significant findings of the current study was the increased serum carcinoembryonic antigen and cancer antigen 15-3 levels in most metastatic breast cancer participants. We postulate that regular measurement of serum cancer antigen 15-3 and carcinoembryonic antigen could be useful for earlier detection and prediction of outcomes.
Authors and Affiliations
Ali Taghizadeh, Leila Pourali, Mona Joudi, Maryam Salehi, Shohreh Eshghi, Farnaz Torabian, Azin Esmaeelpour
Keywords
Related Articles
- EP ID EP443475
- DOI -
- Views 66
- Downloads 0
Thyroid-like Follicular Carcinoma of the Right Kidney: A Case Report
Renal cell carcinoma is responsible for approximately 80% of malignant tumors of the kidney. Clear cell, papillary, and chromophobe forms comprise the most frequent histological subtypes of renal cell carcinoma. Thyroid-...
Radiation Organ Dose Measurement and Cancer Risk Estimation in CT Examination on Trauma Patients
Background: This study intended to measure radiation doses to various organs and calculate the risk of cancer incidence from neck computed tomography and head computed tomography scans of trauma patients by using a therm...
Trends in Cervical Cancer Incidence in Iran from 2003 to 2009
Background: Cancer is the second leading cause of death worldwide and the third in Iran. Among cancers, cervical cancer is the third leading cause of death in women. Thus, recognizing the epidemiology and trends of cervi...
Epidemiology and Histopathology of Breast Cancer in Iran versus Other Middle Eastern Countries
Background: Breast cancer is the most prevalent cancer among females worldwide. This study compares the results of the most cited published Iranian studies and studies from other Middle East countries on breast cancer wi...
Neoadjuvant Chemotherapy and Surgical Options for Locally-advanced Breast Cancer: A Single Institution Experience
Background: Neoadjuvant chemotherapy can downstage the size of the tumor, thus allowing some patients with advanced disease with the option of conservative breast surgery. Our study aims to investigate the effectiveness...