ASSESSMENT OF GASTRIC TUMOURS HIGHLIGHTING GASTROINTESTINAL STROMAL TUMOURS (GIST)- A STUDY OF 75 CASES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 19
Abstract
BACKGROUND Accurate diagnosis of gastric neoplasm is challenging and demands thorough histopathological evaluation. This study laid emphasis on GIST cases and their pattern of immunoreactivity with CD-117 and DOG-1, as on many occasions they are misdiagnosed. Aims and Objectives- To study histopathological features of various gastric tumours and compare the pattern of immunoreactivity of GIST cases with CD-117 vis-a-vis DOG-1. MATERIALS AND METHODS A study of patients with gastric tumours was conducted in a tertiary care hospital including careful examination of haematoxylin and eosin stained sections. Immunohistochemistry was performed for markers DOG-1 and CD-117 in cases diagnosed as GIST. Statistical analysis used- Tables and diagrams depicting data were prepared and analysed using SPSS version 20.0. Categorical variables were expressed as number of patients and percentage of patients and compared using Pearson’s Chi-Square test for independence of attributes. An alpha level of 5% has been taken, i.e. if any p-value is less than 0.05 it has been considered as significant. Settings and Design- It was a descriptive type of study, conducted for a period of two years. RESULTS Gastric tumours are common in age group of 51 - 60 years and in males. Among 75 cases, 54 cases were located at body of stomach. Predominantly, ulcerative growth pattern was observed. 16 cases were suspected to be GIST histopathologically, 44 moderately differentiated adenocarcinoma, 1 poorly differentiated neuroendocrine carcinoma, 5 infiltrating poorly differentiated adenocarcinoma and 9 well differentiated adenocarcinoma. Mostly advanced stage, pT2N1Mx (42.6%) cases were detected. 16 cases were differentially diagnosed as GIST. CONCLUSION Accurate diagnosis of gastric tumours demands thorough histopathological evaluation. DOG-1 has overall superior and crisply localised staining pattern than CD-117.
Authors and Affiliations
Pratyusha Bhattacharjee, Himansu Roy, Saumik Chakraborty
Keywords
Related Articles
- EP ID EP418218
- DOI 10.14260/jemds/2018/531
- Views 88
- Downloads 0
EFFECTS OF AGE, GENDER AND EDUCATION LEVEL ON COGNITION IN ELDERLY PEOPLE
BACKGROUND With rapidly increasing number of older people in our community cognitive impairment is a growing public health concern in India. It affects the quality of life for the person affected and the caregiver. By pr...
ASSESSMENT OF SSG (SALINE SONOSALPINGOGRAPHY) IN ASSESSING TUBAL PATENCY BY COMPARISON WITH CHROMOPERTUBATION IN LAPAROSCOPY
BACKGROUND Objective- To evaluate the test characteristics of transvaginal Saline Sonosalpingography (SSG) for the assessment of tubal patency to compare accuracy, positive predictive value and efficacy of sonosalpingogr...
A STUDY OF NEONATAL SURGERY IN DEVELOPING COUNTRY: MONITORED LOCAL ANAESTHESIA AND SEDATION TECHNIQUE
[b]OBJECTIVE:[/b] The present study is conducted in a tertiary care institute in central India to develop an effective, safe and minimal anaesthesia technique for neonatal emergency surgery. [b]METHODOLOGY:[/b] Pros...
A CLINICAL STUDY OF INTESTINAL OBSTRUCTION AND ITS SURGICAL MANAGEMENT IN RURAL POPULATION
[b]BACKGROUND[/b]: The diagnosis and management of the patient with intestinal obstruction is one of the more challenging emergency that a general surgeon can come across. Although the mortality due to acute in...
COMPARISON OF THIOPENTONE (1.25%) AND PROPOFOL (1%) FOR INSERTION OF LARYNGEAL MASK AIRWAY IN PAEDIATRIC PATIENTS
BACKGROUND Laryngeal mask airway is widely used in management of paediatric anaesthesia. This study has been designed to investigate whether Propofol 1% alone or Thiopentone along with Halothane is suitable agent for LMA...