ASSESSMENT OF GLYCOSYLATED HAEMOGLOBIN LEVELS IN YOUNG HEALTHY KASHMIRI ADULTS
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 9
Abstract
Background: One of the types of haemoglobin present in red blood cells is glycated haemoglobin(HbA1c).This type of haemoglobin is normally present in blood and tells us about the amount of glucose to which the red cell has been exposed during a particular period of time. Hemoglobin A1c (HbA1c) has been used for decades to monitor the control of glycaemia in diabetes. HbA1c has traditionally served as an indicator of glycemic control over the preceding 2 to 3 month period.HbA1c is associated with diabetes & its microvascular complications, macrovascular complications, risk of death and cardiovascular disease. The ultimate cause of microvascular and neuropathic complications is chronic hyperglycemia.Hence Glycated Hb is widely used for monitoring long term glycemic control in known diabetic patients and the prognostic value of glycated Hb has been investigated, in study of patients with normal glucose tolerance. Aims and objectives: Assessment of the normal levels of HbA1c in young healthy adult Kashmiri population for establishing reference values. Materials and Methods: The study was conducted over a period of one year. The venous blood samples were collected from healthy adult Kashmiris of both sexes. The sample size was 500. HbA1c testing was done by using an autoanalyser.A proper consent was taken and other clinical conditions were ruled out. One-way analysis of variance (ANOVA) and student't' test was used to compute statistical inference. Results: In this study there were total of 500 subjects out of which 264 were males and 236 were females. Most number of the patients were of the age group of 20 to 30 years. The males showed higher average HbA1c values as compared to females. The average value observed was 4.566±0.417. In case of males, the mean value of HbA1c was 4.612±0.382 and that for females was 4.513±0.447. Conclusion: The HbA1c values observed in normal adult kashmiri population are well within the standard normal values established by various international studies. This value is an authentic measure of blood glucose levels over a period of time and is a simple and effective investigation to monitor the treatment for diabetes and also predict the future chances of diabetes in healthy individuals.
Authors and Affiliations
Reyaz Lone, Suhail Ahmad Gilkar
Keywords
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