Assessment of Hepatoprotective Potential of Solanum xanthocarpum (whole plant) Linn. Against Isoniazid & Rifampicin Induced Hepatic Toxicity in Wistar rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 5
Abstract
Introduction and objective: The scientific assessment of medicinal plants used in the preparation of folk remedies has contributed modern medicine with effective pharmaceuticals for the treatment of diseases. Objective: The 50% ethonolic extract of solanum xanthocarpum (Solanaceae) whole plant was explored for its hepatoprotective and antioxidant effects on RIF+INH (50 mg/kg) induced acute liver damage in Wistar albino rats. Materials and Methods: The Whole plant (SX) were further subjected to various phytochemical study and the studies conclude the presence of alkaloids, flavanoids, glycosides, protein & amino acid etc. Hepatoprotection activity was measured by using enzymatic (serum glutamate oxalate transaminase and serum Glutamate Pyruvate Transaminase (SGOT and SGPT), alkaline phosphatase (ALP), total bilirubin and non enzymatic parameters (GSH, LPO, SOD, CAT) produced significantly increased and decreases serum level in a dose dependant manner. Results: The Whole plant extract SX at the doses of (125 mg/kg &250 mg/Kg) significant liver protective effect by decreasing the serum enzymatic and non enzymatic parameters, although Histopathological profile of liver at dose level 125 mg/kg showing hepatic cells with well preserved cytoplasm prominent nucleus, some of central vein and sinusoids exhibited congestion. At the same time fourth group test dose at 250 mg/kg showing well brought out central vein, hepatic cell with well preserved cytoplasm prominent nucleus. Conclusion: These all result recommended that 50% ethonolic extract of whole plant of Solanum xanthocarpum posses significant hepatoprotective activity.
Authors and Affiliations
Pritt Verma, Shravan paswan, Surya Prakash Singh, Sajal Shrivastva, Ch. V. Rao
Keywords
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