Assessment of Human Natriuretic Peptides (B), Human N-Terminal Pro-BNP and Nor-epinephrine as Neurohumoral Markers in Sleep Disordered Breathing among Heart Failure Patients in Upper Egypt
Journal Title: UNKNOWN - Year 2017, Vol 7, Issue 6
Abstract
Objective: The purposes of this study are to: (1) Measure neurohumoral activation in heart failure patients with and without Sleep Disordered Breathing; (2) Assessment of neurohumoral markers with the severity of sleep apnea and severity of heart failure. Patients and methods: In this case report study, we studied 100 patients with heart failure (64 male, 36 female). All patients underwent echocardiography and a full night-attended polysomnography, in addition to neurohumoral evaluation. Results: Group (1) sleep Disordered Breathing (SDB) had significant increase in the plasma concentration level of BNP (591.50 ± 165.75 vs. 298.33 ± 86.63 pg/ml, P=0.001*), NT-proBNP (1750.05 ± 773.15 vs. 686.98 ± 377.88 pg/ml, P=0.001*) and nor epinephrine (NE) (616.12 ± 139.57 vs. 203.80 ± 64.30 pg/ml, P=0.001*) when compared with No-SDB. A significant increase in plasma level of NT-proBNP and nor-epinephrine (NE) in OSA was observed when compared with central sleep apnea (CSA). Increased neurohumoral markers with different severity of apnea hypopnea index (AHI). Moreover, a significant increase was observed in neurohumoral markers with increased severity of left ventricular ejection fraction (LVEF). Based on echocardiographic etiology of heart failure, patients with dilated cardiomyopathy had a significant increase in plasma level of BNP and NT-pro BNP. On the other hand, plasma concentration level of norepinephrine (NE) was significantly increased in patients with hypertensive heart disease. Conclusion: Heart failure patients with sleep disordered breathing were associated with higher levels of neurohumoral activation. Moreover N-TproBNP (<300m pg/ml) and nor epinephrine (NE)<300 pg/ml were predictors of OSA among heart failure.
Authors and Affiliations
Suzan Salama, Amany Omar, Mahmoud A Sabour, Doaa Magdy, Mohamed Ismail Seddik
Keywords
Related Articles
- EP ID EP387154
- DOI 10.4172/2167-0870.1000333
- Views 58
- Downloads 0
Feasibility Study of Bolus 5-Fluorouracil+L-Leucovorin as Salvage Line Chemotherapy for Oral Fluorouracil-Resistant Unresectable Gastric Cancer: Hokkaido Gastrointestinal Cancer Study Group Study HGCSG1502
In November 2015 we began a feasibility study of salvage line chemotherapy with 5-fluorouracil and l-leucovorin given in an intravenous bolus once weekly followed by a 2-week rest period within a 8-week cycle in patients...
Toward a Comprehensive and Accurate Measure of Clinical Trial Workload, Equity, Quality Assurance and Patient Safety-How Much Workload is Too Much? Commentary and Brief Research Report
This article provides a brief commentary on the methodology surrounding controlled clinical trials, the growing trend of centers conducting multiple controlled trials (i.e. “factory science”), trial workload measures, an...
Preparation with Mechanical Bowel Cleansing or/and Oral Antibiotics or Nothing for Elective Colorectal Surgery: Two-Two-Arm Multicentre Randomised Controlled Studies (MECCLANT –C and –R Trials)
Background: Based on sound evidence, traditional mechanical bowel preparation for elective colorectal surgery has mostly been abandoned during the last two decades. However, more recent evidence from USA large databases...
Diffuse Juvenile Xanthogranuloma: A Case Report
Juvenile xanthogranuloma (JXG) is a benign Non-langerhancian histiocytic proliferation. Herein, we report the case of a 17-month-old infant, who presented with two months history of a diffuse asymptomatic papular eruptio...
Drug-Eluting vs. Bare-Metal Stents: Is it a Matter of Vessel Size?
Background: Although drug-eluting stents (DES) for percutaneous coronary intervention have dramatically reduced the incidence of in-stent restenosis, their deployment for large-size coronary lesions is still controversia...