Assessment of Interleukin (8) in Type 2 Diabetes Mellitus

Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 4

Abstract

<strong>Background: </strong>Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long- term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Type 2 diabetes (T2D) is characterized by a condition of systemic low-grade inflammation. IL-8 is an important member of the chemokine family of proinflammatory chemotactic cytokines. IL-8 was initially characterized as a potent chemoattractant of neutrophils and was later shown to also activate neutrophils. IL-8 is also known to be a potent promoter of angiogenesis. <strong>Objective: </strong>It was the Assessment of Interleukin (8) in Type 2 Diabetes Mellitus. <strong>Patients and Methods: </strong>Serum IL 8 level in Type 2 Diabetes Mellitus. 30 patients compared to 30 normal individuals were included in this study. <strong>Results: </strong>There was a highly statistical significant difference between all patients and control groups as regard serum IL 8 level (mean of serum IL 8 in patients and control groups were 69.9 ± 20.5 and 5.4 ± 3.3 respectively, p= < 0.001). <strong>Conclusion: </strong>Type 2 diabetes mellitus patients showed marked elevation of circulating IL-8 levels which identify subjects with worse inflammatory state and metabolic control and therefore it may be used as a marker for the rate of development of diabeteic complications.

Authors and Affiliations

Eman Helal

Keywords

Related Articles

Non-Alcoholic Fatty Liver Disease

<strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease that exposes patients to a great risk of emerging cardiovascular diseases and could develop to cirrhosis or...

MRI Evaluation of Lumbar Disc Degenerative Disease

Aim of the work: lumbar disc degenerative disease is most leading cause of back pain, it is the most common cause of disability at age above 45 years and 2nd most common reason for primary care physician visit. Magnetic...

Effect of Chest Physical Therapy Modalities on Oxygen Saturation and Partial Pressure of Arterial Oxygen in Mechanically Ventilated Patients

<strong>Background: </strong>Chest physical therapy plays an important role in increasing Pao2 and SaO2 among ICU patients which is considered as a good indicator for the general improvement of the patient besides decrea...

Maternal Serum Amyloid A level in Pregnancies Complicated with Preterm Premature Rupture of Membranes

Background: serum amyloid A (SAA) is a cytokine-inducible acute-phase reactant whose plasma concentrations can exceed 1 mg/mL during an acute-phase response (500 to 1000 fold of plasma levels greater than in the non inf...

A Comparative Study of Primary Colonic Repair versus Stoma in Emergency Cases

<strong>Background: </strong>In emergency surgery, management of an enterotomy, either spontaneous or following resection of a bowel segment can be by approximation of cut edges, referred to as primary repair or by exter...

Download PDF file
  • EP ID EP584150
  • DOI 10.12816/ejhm.2018.9298
  • Views 94
  • Downloads 0

How To Cite

Eman Helal (2018). Assessment of Interleukin (8) in Type 2 Diabetes Mellitus. The Egyptian Journal of Hospital Medicine, 72(4), 4403-4406. https://europub.co.uk/articles/-A-584150