Abstract

Objective: To assess lipid profile in patients with HIV positive infection and to correlate the variation in lipid profile with the CD4+ and CD8+ cell count and establish the relationship between the variables. Methods: Ninety-one participants were enrolled for the present study of which forty seven patients were HIV positive patients and forty four were controls. The study was carried out at College of Medicine & JNM Hospital, Kalyani. Ten mL of blood samples were collected from the participants. The CD4 and CD8 lymphocyte count was estimated by Fluoresence Activated Cell Sorter (FACS) count system (Becton Dickinson). Lipid profiles were analyzed enzymatically using kit obtained from Randox Laboratories Limited, Crumlin, UK. Results: The changes in total cholesterol (TC), HDL-C, TC/HDL-C and age were not significant when compared between cases and controls. Significantly higher levels of triglycerides, low-density lipoprotein-cholesterol (LDL-C), LDL /HDL-C, TG/HDL-C and CD4/CD8 ratio were observed along with decline in CD-4 cells/毺 L, CD-8 cells/毺 L (P=0.0001). Furthermore there was a strong correlation between CD-4 cells/毺 L and TG, LDL-C. Also triglycerides and LDL-C level increased proportional to the increase in CD-4 cells/毺 L. Conclusions: It can be concluded that the changes in lipid profile can be a good index of disease progression in HIV infection.

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