Assessment of Liver Fibrosis by Transient Elastography and APRI (AST to Platelet Ratio) in patients with Chronic Liver Disease.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 1
Abstract
Liver biopsy being the ‘gold standard’ is an invasive investigation; many non-invasive markers are being investigated for prediction of hepatic fibrosis. We aim at assessing the liver fibrosis by Transient Elastography and APRI (AST to PLATELET RATIO) in Chronic Liver Disease. 64 patients of CLD and 64 healthy subjects were included in the study. Transient Elastography was done using FIBROSCAN® and APRI score was calculated. Predominant etiology was CALD (50%) followed by HBV (32.8%) and HCV (17.2%). The mean LSM and APRI score for cases and control was 36.06±24.18kPa, 2.47±2.05 and 3.96±0.97kPa, 0.45±0.16 respectively. AUC (95%CI) for diagnosis of significant fibrosis by Transient Elastography and APRI was 0.99 (0.98-1.01) and 0.91 (0.85-0.96) respectively. The optimal LSM value was 4.5 kPa for diagnosis of significant fibrosis with specificity, sensitivity, PPV and NPV of 70.3 %, 98.4%, 76.8%, 97.8% respectively. The optimal APRI score was >0.70 for diagnosis of significant fibrosis with specificity, sensitivity, PPV and NPV of 90.6%, 81.3%, 89.7%, 82.9%. Correlation value of r = +0.379 was established between Fibroscan® and APRI score in cases. TE is superior to APRI for non-invasive diagnosis of fibrosis. TE and APRI score are positively correlated with fibrosis in patients with CLD.
Authors and Affiliations
Ajay Pratap Singh, Ravi Misra
Keywords
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- EP ID EP575673
- DOI 10.9790/0853-1701037985.
- Views 67
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