Assessment of Normal Cerebral Sulcal Development in Foetus Using MRI
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Aim: The timing of the appearance of different types of sulci in a foetus is so precise that neuropathologists consider gyration to be a reliable estimate of gestational age and consequently a good marker of fetal brain maturation. The aim of this study is to provide a standard of reference that can be used to assess normality of fetal sulcation. Materials & Methods : Foetal MRI of 74 ultrasonically labelled normal fetuses of gestational age 22 to 36 weeks is done using standard turbo spin echo sequence (HASTE) by focussing on Foetal brain . Assessment of cerebral sulcation is then done by two experienced radiologists having blinded from gestational age of the foetuses . Total of 17 sulci are analysed e in an orderly manner starting from sulci present in medial cerebral surface,followed by ventral cerebral surface and then those present in vertex . The identified sulci were categorized in to three catagories – present, absent and partially developed. Results: Based on the observation, the gestational age at which each sulci can be identified and gestational age after which each sulci should be visualized are tabulated . Sequential development of the various sulci is consolidated and as a result 6 stages of cerebral sulcal development is proposed Conclusion: This study provide a sequential stages of in utero sulcal development by which the evaluation of fetal brain maturation in relation to gestational age can be done during the second and third trimesters especially to identify early brain anomalies involving neuronal migration and cortical formation . .
Authors and Affiliations
Sathyan Gnanasigamani, Periakaruppan Alagappan, Amarnath Chellathurai, Rajakumari Thirumaran, Sivakumar Kannappan, Balaji Ayyamperumal
Keywords
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- EP ID EP363002
- DOI 10.9790/0853-1702094453
- Views 74
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