ASSESSMENT OF PHARMACEUTICAL PROPERTIES OF GYNAECOLOGICAL HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2012, Vol 0, Issue
Abstract
Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5-25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. The addition of glycerol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 23 cm to 26 cm and at 2:1 ratio from 25 cm to 29 cm. Gels with addition 20-25% poloxamer 407 containing lactic acid complexed with chitosan and 5-25% content of glycerol reveal pH from 4.25 to 4.98 for 1:1 and from 3.60 to 4.45 for 2:1. The investigations showed that the addition of a thermosensitive polymer increases the adhesive properties of the investigated gels, but at the same time it increases their pH. The addition of glycerol or 1,2-propylene glycol reduces the pH and maintains high adhesion. The use of hydrofilizing substances allowed to obtain physiological range pH gynaecological gels.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
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- EP ID EP73574
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