Assessment of Propofol and Etomidate for General Anaesthesia-Hemodynamic Changes and Complications
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 8
Abstract
Background: Inducing agents aredrugs when given intravenously cause rapid loss of consciousness. Etomidate and propofol are ultra-short-acting tranquillizing agents that provide these characteristics.Few of the side effects that occur with Propofol are blood pressure drop, ventilation depression in a dose dependent manner and pain during injection.The present study was done to assess the hemodynamic changes and complication occurring with Propofol and etomidate during general anesthesia. Materials & Methods: The present study enrolled 60 subjects that belonged to ASA grade I and II. The subjects undergoing surgical treatment under general anesthesia were enrolled in the study. Group I subject received 1% Propofol injection and Group II subjects received 0.3mg/kg of etomidate. Pre-medication was given with 0.25 mg alprazolam tablets and 150 mg ranitidine tablets. Patient’s myoclonic activity and pain during injection were recorded at the time of induction. All the data was arranged in a tabulated form and analyzed using SPSS software. Student t test was used for analysis and probability value of less than 0.05 was considered as significant. Results: Table I shows that out of 60 patients, 30 were in group I and 30 in group II. The male to female ratio in Group I was 2:1 and in Group II was 1:1. In group I, a significant decrease in MAP from baseline at induction with Propofol was seen compared to etomidate. The mean arterial pressure of both the groups was comparable (p> 0.05). In group II, number of patients with grade I, grade II and grade III pain were 25 (83.3%), 3 (10%) and 2(6.7%) respectively. The difference was statistical significant (p- 0.02). Conclusion: From the present study we can conclude that etomidate is a improved option amongst patients especially those who are prone to hemodynamic changes
Authors and Affiliations
Raju Jharbade, Sunita B. Wadekar, Sunita Dhupia, Neil Alwani, Santosh Pancholi
Keywords
Related Articles
- EP ID EP549013
- DOI -
- Views 137
- Downloads 0
Effect Of Local Periodontal Treatment Alone And In Combination With Systemic Doxycycline Therapy On Glycaemic Control In Patients With Type-2 Diabetes Mellitus
Background: Evidence consistently shows that Periodontal infection may adversely affect glycaemic control in people with diabetes. In the light of this background this study aims to examine the effects of non-surgical p...
Implants and Magnets as Retentive Aids in Maxillofacial Region- A Review of Literature
Patients with facial or intraoral defects will seek treatment to address the loss of comfort, function or natural appearance. It is maxillofacial prosthodontist’s responsibility to provide prostheses that do not injure t...
Colour Constancy of Dental Porcelain after Exposure to Universally Consumed Beverages: A Methodical Review of Literature
For dental porcelain, precise shade matching of tooth coloured restoration with the adjacent dentition is deemed necessary. However the colour instability in porcelain restoration is a common problem now a day’s particul...
Calculi – A Review
A calculus (plural calculi), often called a stone, is a concretion of material, usually mineral salts, that forms in an organ or duct of the body. Small sized calculi remain completely asymptomatic and are poorly localis...
Vaccination against Dental Caries – Possibilities, Prospects & Dangers
In spite of the rise in the understanding and dental technology, dental caries stays a standout amongst the most widely recognized irresistible ailments of humankind. Smaller scale life forms that are found to be carioge...