Assessment of Proteinase-Inhibitory System and Plasma Fibrinolytic Activity in Patients with Gastroesophageal Reflux Disease and Diabetes Mellitus Type 2
Journal Title: Гастроентерологія - Year 2016, Vol 4, Issue 62
Abstract
Aim: investigation of proteinase-inhibitory system and plasma fibrinolytic activity in patients with gastroesophageal reflux disease (GERD) combined with diabetes mellitus (DM) type 2. Methods. The study involved 112 patients with GERD aged 33 to 76 years, who subsequently were divided into groups depending on the form of GERD. The state of proteinase-inhibitory blood system was evaluated by K.N. Veremeyenko et al.. The state of enzymatic and non-enzymatic fibrinolysis in plasma was evaluated by N. Titsa method. Results. We found that patients with erosive form of GERD independent on DM type 2 more likely have higher level of low molecular and macromolecular proteins lysis as well as collagen lysis compared to the healthy person and patients with non-erosive form of GERD (p < 0.05). The changes in the concentration of α2-MG in GERD were multidirectional: reduced concentration of α2-MG in GERD combined with DM type 2, and vice versa, increased level of α2-MG in patients with GERD without comorbid pathology compared with the healthy person. Assessment of plasma fibrinolytic activity found that patients with erosive form of GERD combined with DM type 2 had significantly increased fibrinolytic activity compared to the healthy person (p < 0.05), and in patients with nonerosive form of GERD and DM type 2 just had trend to increase in these indicators (p > 0.05). Novelty. First studying changes of proteolytic and fibrinolytic activity of blood and inhibitor of proteolysis allowed reveal new mechanisms of pathogenesis and progression of GERD in patients with DM type 2. Conclusion. Thus, in patients with GERD combined with DM type 2 met unbalanced growth of the intensity of proteolysis under the conditions of reduced expression of its inhibitor, increased plasma fibrinolytic activity.
Authors and Affiliations
Yu. V. Kohanyuk, O. I. Fediv, L. M. Goncharuk
Keywords
Related Articles
- EP ID EP210199
- DOI 10.22141/2308-2097.4.62.2016.81084
- Views 71
- Downloads 0
First district sanitary doctor of Katerynoslav
The life and professional activity of Vasyl Tymofiiovych Skrylnikov — a famous doctor-hygienist, scientist, and public figure have been represented. V.T. Skrylnikov contributed to the development of sanitary-prophylaxis...
Manometry for studying motor functioning of upper digestive tract
Impaired motility of esophagus, stomach, duodenum can be a key pathogenetic factor for development of most common diseases of digestive tract. Motility observation is of great importance for the assessment of digestive t...
The Role of Phosphatidylcholin for Correction of Hepatobiliary Disorders at Enteropathy
The article considers the hepatobiliary disorders at enteropathy, therapeutic strategy for hepatobiliary disorders in enteripathy. There have been presented the results of our own investigations of the effectiveness of E...
Surgical Correction of Structural and Functional Liver Diseases in Patients with Chronic Calculous Cholecystitis and Its Long-Term Results
During surgery for chronic calculous cholecystitis in 52 patients after the morphological confirmation of hepatic steatosis we have carried out surgical correction of structural and functional changes in the liver with p...
Liver disorders in patients with ulcerative colitis
Background. The article deals with the chronic inflammatory bowel diseases, in particular, the attention is paid to ulcerative colitis (UC). UC proceeds with the development of a number of extraintestinal lesions, among...