Assessment of Prothrombin Time, Activated Partial Thromboplastic Time Platelets Count and Serum Alpha Amylase in Acute Pancreatitis Sudanese Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Background: Acute pancreatitis is a sudden inflammation that lasts for a short time. It may range from mild discomfort to a severe, life-threatening illness.Acute pancreatitis (AP) is a potentially lethal disorder with no specific medical treatment. AP is characterized by a spectrum of symptoms, ranging from a local inflammatory process to more severe form (acute necrotizing pancreatitis). In addition, pancreatitis may be further classified into acute interstitial and acute hemorrhagic disease. In the first type, the gland architecture is preserved but is edematous. Inflammatory cells and interstitial oedema are prominent within the parenchyma. Haemorrhagic disease is characterized by marked necrosis, haemorrhage of the tissue, and fat necrosis . There is marked pancreatic necrosis along with vascular inflammation and thrombosis. Severe acute pancreatitis may cause dehydration and low blood pressure. The heart, lungs, or kidneys may fail and if bleeding occurs in the pancreas, shock and even death may follow . Objective: The purpose of this study was to assess of Prothrombin Time, Activated Partial Thromboplastic Time, Platelets count and serum amylase in acute pancreatitis Sudanese patients. Materials and Methods: This study a case control study , that included Sixty samples to assess Prothrombin Time(PT) , Activated Partial Thromboplastic Time(APTT) , Platelets countand serum amylase in acute pancreatitis Sudanese patients. 30 samples were collected from patients (case group) and 30 samples were collected from healthy persons which represented the control group.This study was approved by ethical committee of ministry of health, and informed consent was obtained from each participant before sample collection.Data was be collected by a structured questionnaire system from patients inIbnSenahospital. The PT ,APTT was done by semi-automated coagulometer (COATRON-MI) and platelate by using Sysmex Kx-21N.the data analyzed using SPSS21. Results: In this study the mean± SD of age PT, PTT and Platelets in case group were59.33 (± 7.36), 31.06 (± 6.29) seconds, 57.33 (± 9.20)seconds and 306.53 (± 60.44)x109 /µL respectively, While the mean± SD of PT, PTT and Platelets in control group were 13.33 (±1.15)seconds , 34.94 (± 2.59)seconds and 287.43 (± 47.59)x109 /µLrespectively.the difference was statistically significant (P=0.00) Conclusion: This study concluded that PT and APTT were prolonged in patients with acute pancreatitis compared to the normal subjects and Platelets count was within normal range in all patients.
Authors and Affiliations
Amna Siddig Hamdan Obied, Dr. Amira Ahmed Khalid Humeida
Keywords
Related Articles
- EP ID EP597563
- DOI 10.9790/0853-1605070509.
- Views 66
- Downloads 0
Histopathological Study of Spectrum of Ovarian Tumors – A 2 Years Study in a Tertiary Care Institute
Introduction:Ovarian tumours are heterogeneous neoplasms with varied clinical, morphological and histological features. Ovarian tumours account for 3% of cancers in females and is the 5th most common form of cancer relat...
“A Clinical Study of Cutaneous Manifestations in Paediatric Age Group”
Background: Pediatric dermatoses are distinct group of disorders, comprising of skin problems encounteredduring childhood and adolescence. Skin diseases are a major health problem in the peadiatric age group which vary i...
Relationship between Haemoglobin Genotype, Incidence of Diabetes Mellitus and Some Clinical Complications in Southern Nigeria Tertiary Health Institutions
Established association exist between haemoglobin genotype and protection against or susceptibility to some disease conditions. We investigated the relationship between haemoglobin genotypes, incidence of diabetes mellit...
“Endoscopic Versus Open Surgical Techniques in the Management of Renal and Ureteric Calculi”
Although stone disease is one of the most common affliction of modern society, it has been described since antiquity. With westernisation of global culture however, the site of stone formation has migrated from the lower...
A Prospective Study to Assess the Accuracy of Diagnostic Focussed Abdominal Sonography For Trauma (Fast) In Blunt Abdominal Trauma Among the Patients Presenting To Govt Rajaji Hospital Madurai
Background & Objective: In view of increasing number of road traffic accidents and blunt abdominal injury and its lethal & fatal complications ,FAST is an essential and necessarycomponent of trauma management.Hence this...