Assessment of Quality of Life of Patients with Chronic Hepatitis B and C Treated with Pegylated Interferon-alpha
Journal Title: Viral Hepatitis Journal - Year 2018, Vol 24, Issue 2
Abstract
Objectives: It was aimed to evaluate health-related quality of life of patients with non-cirrhotic chronic hepatitis B (CHB) and chronic hepatitis C (CHC) during interferon therapy with the standard short form-36 (SF-36). Materials and Methods: This study included all patients who attended the Atatürk University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology and outpatient clinics for treatment between June 2008 and June 2010 and met the inclusion criteria. A socio-demographic data questionnaire and SF-36 were administered in all subjects before the interferon therapy and in the third and sixth months of the treatment. Results: Before the treatment, vitality/energy (p=0.01) and general health (p=0.01) scores in patients with CHB were lower than in controls. In the sixth month of the therapy, physical function (p=0.03), role physical (p=0.011), role emotional (p=0.003) and vitality/energy (p=0.005) scores were significantly lower than in controls. There was a significant difference in physical function (p=0.006), role physical (p=0.006), role emotional (p=0.001) and vitality/energy (p=0.000005) scores before the treatment and physical function (p=0.006), role physical (p=0.013), role emotional (p=0.001), vitality/energy (p=0.000005) and mental health (p=0.041) scores in the third month of the treatment and physical function (p=0.000008), social function (p=0.005), role physical (p=0.0000008), role emotional (p=0.000007), mental health (p=0.001) and vitality/energy (p=0.000005) scores in the sixth month of the treatment between patients with CHC and controls. Conclusion: Providing guidance and counseling to patients with CHB and CHC about their illness and side effects of the drugs will increase health-related quality of life of patients and will adapt them to their treatment.
Authors and Affiliations
Handan ALAY, Kemalettin ÖZDEN, Serpil EROL, Neslihan ÇELİK, Emine PARLAK, Mehmet PARLAK
Keywords
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- EP ID EP382481
- DOI 10.4274/vhd.2017.0016
- Views 33
- Downloads 0
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