Assessment of Renal Function of Eritrean Diabetic Patients Using the GFR derived from the Serum levels Creatinine, Cystatin C or Creatinine- Cystatin C
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 3
Abstract
Renal insufficiency in one of the most common complication in diabetic patients and in clinical practice renal function status is assessed using serum creatinine or its derivative eGFR. Recently Cystatin C is believed to be more sensitive for assessing renal function. A cross sectional descriptive study on 100 known 51 female ad 49 male diabetic patients whom are on regular follow up at diabetic clinic in Eritrea from Oct 2014 to Jan 2015. The aim of the study was to evaluate the renal function status and glycemic control of diabetic patients based on serum creatinine, cystatin C, and HbA1C, respectively. Demographic data was analyzed using structured questioner and serum creatinine, Cystatin C, HbA1C and fasting blood glucose was determined. Data was calculated using SPSS version 19. Their age range from 12-89 years with mean (SD) 56(16.3) years and the serum creatinine ranges from 0.5-1.5 mg/dl and only 2 diabetic patients had abnormal serum creatinine, on the other hand serum cystatin C ranges from 0.5 to 2.5mg/dl and about 50 diabetic patients with high level above normal reference value. About 47 cases has poor glycemic control (HbA1C > 7.6%). Serum creatinine based GFR had shown about 75% of the cases fall on the normal range (>90ml/min/1.73m2) However, based on serum Cystatin C only 22% of the cases fall on normal range and the rest were distributed into minimal, moderate, and high risk group stage. The study concluded that, serum Cystatin C based assessment is more sensitive and accurate to evaluate the kidney function status in diabetic patients and the study recommend that it is high time to introduce it in clinical practice to monitor the diabetic patient for possible risk and early detection of renal complication and further study can be performed in a larger sample size. Keywords: Serum creatinine, Serum Cystatin C, Renal Failure, Eritrean Diabetic Patients.
Authors and Affiliations
Shamseldin M. Ahamed, Rustom Zeratsion, Imadeldin Elfaki, GadAllah Modawe
Keywords
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