Assessment of Salivary Immunoglobulin A, a-amylase, pH and Flow-rate Effects on Dental Caries Experience of Down’s Syndrome Children in Makkah, Saudi Arabia
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 3
Abstract
Objective: To assess the association between dental caries experience and salivary Immunoglobulin A, a-amylase, pH and flow-rate in Down’s syndrome children. Materials and Methods: One-Hundred Down’s syndrome participants and one-hundred three healthy controls aged from 4 to15 years were examined to evaluate the caries experience using deft and DMFT. Unstimulated saliva was collected to assess the flow-rate, pH, sIgA and a-amylase. The total sIgA and a-amylase concentrations were measured using ELISA. Data analysis was performed using SPSS® v.20.0 software. Any p value ≤0.05 considered as significant. Results: The deft of deciduous dentition presented significantly lower mean values in Down’s syndrome children compared to the control. While the DMFT index of permanent dentition presented significantly higher mean values in Down’s syndrome children compared to control group. Moreover, the salivary flow-rate and IgA were significantly higher in the Down’s syndrome children. While the Salivary pH and a-amylase showed significantly diminished mean values in Down’s syndrome compared to the controls. Conclusion: In children with Down’s syndrome, the enhanced levels of salivary IgA, pH and flow-rate yielded a protective effect against dental caries.
Authors and Affiliations
Ohud S Alzughaibi
Keywords
Related Articles
- EP ID EP368747
- DOI -
- Views 89
- Downloads 0
Rare Presentation of Recurrent Hydatid Cysts
Cystic echinococcosis (CE) is a widely endemic helminthic disease caused by infection with larval stage of the Echinococcus granulosus tapeworm. Large number of people are affected by CE due to presence E. granulosus on...
Stress and Diabetes Mellitus
Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia that results from an alteration of the secretion or action of insulin. Modern lifestyle including unhealthy diet, a sedentary lifestyle...
Role of Nucleic Acid Amplification Testing in Blood Banks: Additional Measure for Blood Safety
Introduction: Blood safety is a challenging task as millions of people worldwide receive blood transfusion or blood-derived products annually. The Risk of transfusion transmitted infection (TTI) with blood borne diseases...
A Cross-Sectional Study of Assessment of Vaccine Wastage in Tertiary Care Centre of Central India
Background: Development of vaccine was one of the greatest discoveries as it saved thousands of lives over the period. India has one of the largest Immunization program in the world. Routine immunization is one of the mo...
Correlation of Functional Capacity and Disease Severity Indices with Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
Background: Chronic Obstructive Pulmonary Disease (COPD) reduces exercise capacity which in turn restricts patient’s ability to carry out daily activities and affects Quality Of Life (QOL). Six minute walk test is a simp...