Assessment of sCD36 levels and Lipids in Type II Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Background: Cluster determinant 36 (CD36) is a fatty acid translocase which is expressed in variety of cells. Increased expression of CD36 is observed in liver, adipose tissue and skeletal muscle. Non-cell bound CD36 was identified in human plasma and was termed soluble CD36(sCD36) and its level parallels with the increased expression of CD36 observed in various cell types. In diabetes mellitus (DM) the cellular uptake of fatty acids is increased and is associated with insulin resistance and atherosclerosis. Various studies showed elevated sCD36 its association with insulin resistance and atherosclerosis. The aim of the present study is to determine the association of sCD36 with type II DM. Methods: This was a cross-sectional study, and participants were classified as healthy controls and T2DM patients. We estimated FPG, HbA1c, and lipids in them. A quantitative ELISA was used to assess sCD36 levels. Correlation analysis was performed between sCD36 and Triglycerides (TG). Results: A total of 65 subjects were included, 25 healthy controls and 40 T2DM were included in the study. Elevated levels of sCD36, HbA1c and lipids was observed in cases when compared to controls. Median serum concentrations of sCD36 in healthy controls and type 2 Diabetics are 254 and 462 ng/L respectively and it is statistically significant (p 0.01). The median values for FPG, TG, VLDL in cases were 152.5 (mg/dL), 154.5 (mg/dL) and 31 (mg/dL) respectively and it is significantly higher in cases than controls. But there was no significant association between CD36 & TG. Conclusion: Soluble CD36 (sCD36) identified in human plasma is associated with insulin resistance, Type II DM, atherosclerosis and plasma sCD36 levels reflects its tissue expression. In our study we observed elevated sCD36 levels in type II DM when compared to controls. The findings of our study suggests sCD36 may be used as a marker of insulin resistance.
Authors and Affiliations
N. N. Sreedevi, Ratna Deepika Mattaparthi, K. S. S. Saibaba, Siraj Ahmed khan, Noorjahan . , Iyyapu Krishnamohan, B. Yadagiri, M. Vijaya Bhaskar.
Keywords
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- EP ID EP377208
- DOI 10.9790/0853-1707030610.
- Views 83
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