Assessment of Serum Cystatin-C and Serum Creatinine Levels among Sudanese Patients with Diabetes Mellitus in Khartoum State
Journal Title: Scholars International Journal of Biochemistry - Year 2018, Vol 1, Issue 4
Abstract
Diabetes mellitus is a metabolic disorder resulting from insufficient insulin secretion, inefficient insulin action or both which lead to increased blood glucose, Diabetes is the most common cause of End Stage Renal Disease (ESRD). Approximately 40% of patients with type 1 and 15% of patients with type 2 Diabetes eventually develop ESRD. The aim of this study was to assess the level of serum Cystatin-C and Creatinine among Sudanese patients with diabetes mellitus. a cross-sectional study was conducted during the period from May to Jun 2017, sixty samples from diagnosed patients with diabetes mellitus (admitted to Eltayeb said make in Khartoum state) as cases, the level of serum Cystatin-C and Creatinine were measured by I-chroma device and Mindray BS 120 method, Data analysis was carried out by SPSS version 16. The level of serum Cystatin-C and serum Creatinine showed significantly increased in patients with type2 diabetes mellitus when compared to patients with type1 DM with (P.value =0.014 and 0.000) respectively, (the Mean±SD of serum Cystatin-C was 1.03±0.11mg/l, 1.28±0.38mg/l in type1 and tyoe2 DM respectively), and (Mean±SD of serum Creatinine was 0.69±0.10mg/dl, 0.91±0.14 in type1 and type 2 DM respectively), also The level of serum Creatinine showed significant increased in male patients with diabetes mellitus when compared to female patients with diabetes mellitus with (P.value = 0.033), (the Mean±SD = 0.96±0.12mg/dl, 0.87±0.15mg/dl in male and female respectively), and also The level of serum Cystatin-C showed insignificant variation in patients with diabetes mellitus when compared according to gender with( p-value =0.411), Also there was positive correlation between level of Cystatin-C, Creatinine and duration time of diabetes mellitus with (R= 0.810, p-value= 0.000, R= 0.423 and P-value=0.004) respectively. The level of Cystatin-C and Creatinine increased in type2 diabetic patients and also there was a positive correlation between the level of Cystatin-C, Creatinine and duration time of diabetes mellitus and age.
Authors and Affiliations
Gammar Mokhtar Ali, AbdElkarim A. Abdrabo
Keywords
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