ASSESSMENT OF SERUM PARAOXONASE-1 ENZYME ACTIVITY, MALONDIALDEHYDE AND VITAMIN-C IN ORAL PREMALIGNANCIES
Journal Title: International Journal of Clinical and Biomedical Research - Year 2018, Vol 4, Issue 3
Abstract
Background: Oral premalignancies are a group of disease or syndromes which if left untreated can lead to cancer. It carries a great significance in Indian perspective. The actual figure of oral cancers arising from oral premalignancies is not known and to predict accurately the malignant transformations of them is still not possible. Oxidative stress is a known player behind cancerogenesis. Recently decreased Paraoxonase-1 activity and increased oxidative stress markers ware found to be associated with Oral Squamous Cell Carcinoma. So, there is a strong possibility of a similar finding in Oral Premalignancies too. Aim: This study aims to investigate the correlation between serum PON-1 activity and oxidative stress markers (MDA & Vitamin C) in patients with Oral Premalignancies. Material and Methods: A total of 62 patients with clinically diagnosed oral premalignant lesions and diseased controls were chosen for the study. Venous blood samples were collected and PON-1, MDA (in serum) & Vitamin c (in plasma) were analysed spectro-photometrically. Results: significant decreased serum PON-1 activity (P<0.05) and concomitant significantly increased serum MDA (P <0.05) and decreased Vitamin C levels (P<0.05) were observed in premalignancies compared to the controls. These finding were more pronounced in Oral Leukoplakia (OL) than in Oral Submucous Fibrosis (OSMF) with a significant difference. Mean levels of the analysed parameters differed accordingly in the clinical grades of oral premalignancies. Conclusion: It can be envisaged that serum PON-1 activity and increased oxidative stress might be a contributing factor behind pathogenesis and progression of Oral Premalignant Diseases.
Authors and Affiliations
Kar Param, Mohod Kanchan, Puttewar Manish, Kumar Satish
Keywords
Related Articles
- EP ID EP469954
- DOI 10.31878/ijcbr.2018.43.05
- Views 127
- Downloads 0
GENES BIOMARKERS IN AUTISM: BRAIN DEVELOPMENT AND FUNCTION
Autism is childhood neuropsychiatric disorder despite exhibiting high heritability and has largely eluded efforts to identify specific genetic variants of biomarkers. This neuropsychiatric disorder is characterized by so...
A STUDY ON RECTAL CARRIAGE OF MULTIRESISTANT GRAM-NEGATIVE BACILLI IN CHILDREN ATTENDING PEDIATRIC HOSPITAL AMBOHIMIANDRA, MADAGASCAR
Introduction: Gram-negative bacilli are often responsible for rectal colonization in children. These bacilli normally sensitive to third generation cephalosporins (3GC) have acquired disturbing antibiotic resistance...
ASSESSMENT OF LEVELS OF PHYSICAL ACTIVITY IN PERIMENOPAUSAL WOMEN
Aim: Various physical, psychological and hormonal changes during the perimenopause may affect their quality of life. It results in Joint pain, stiffness and urinary incontinence may limit the ability to take the exe...
A STUDY OF OUTCOME OF ROSE K LENSES IN KERATOCONUS
Background: Cornea is affected by several distinct disorders that produce marked thinning without significant inflammation. They are keratoconus, posterior keratoconus, pellucid marginal degeneration, and keratoglob...
CYBER PORNOGRAPHY ADDICTION AMONGST MEDICAL STUDENTS OF WESTERN RURAL MAHARASHTRA
Introduction: Cyberpornography is an act of using cyberspace to create, display, distribute, impart or publish pornography or obscene materials, especially materials depicting children engaged in sexual acts with adults....