Assessment of serum uric acid levels in Type 2 diabetes mellitus patients
Journal Title: International Journal of Medical Science and Public Health - Year 2017, Vol 6, Issue 12
Abstract
Background: Diabetes mellitus is a metabolic disorder of carbohydrate metabolism, producing hyperglycemia and is affected by factors like insulin resistance. Hyperglycemia can produce reactive oxygen species or free radicals due to its effects on various pathways. These free radicals may lead to oxidative stress in diabetes and as a preventive measure; the body may increase its preventive antioxidants. Objectives: Uric acid is considered to be an antioxidant and this study was undertaken to understand the relation of serum uric acid levels in Type 2 diabetes patients. Materials and Methods: A crosssectional study was done and included 100 individuals (50 Type 2 diabetes cases and 50 normal controls). Fasting blood glucose level and 2-h postprandial blood glucose level were estimated by glucose oxidase-peroxidase endpoint method, and serum uric acid levels were measured by uricase-trinder endpoint method on fully automated chemistry analyzer. Results: Serum uric acid levels were significantly elevated in Type 2 diabetes patients group as compared to nondiabetic controls. The mean uric acid level in cases was found to be 8.02 ± 1.86 mg/dl, whereas in controls, it was found to be 3.73 ± 1.06 mg/dl. The difference was statistically significant (P < 0.05). Conclusion: Monitoring of serum uric acid levels in persons having Type 2 diabetes can help in knowing the effects of oxidative stress in these cases and can be used as an aid to other tests.
Authors and Affiliations
Gagandeep Kaur Sidhu, Ruhan Oza, Asha S Khubchandani, Bhavesh Prajapati
Keywords
Related Articles
- EP ID EP333188
- DOI 10.5455/ijmsph.2017.1027618102017
- Views 97
- Downloads 0
A study on reasons for nonadherence to 99DOTS among HIV-tuberculosis coinfected patients in Davanagere district, Karnataka
Background: Ensuring the patient’s adherence is the critical challenge in tuberculosis (TB) treatment. To monitor the adherence to anti-TB drugs in HIV-TB coinfected patients, 99 directly observed treatment short (99DOTS...
Cognitive functioning in Wernicke’s encephalopathy following chronic alcoholism
Background: Wernicke’s encephalopathy (WE) is an acute neuropsychiatric syndrome caused by a deficiency of thiamine (Vitamin B1) in chronic alcoholics. In chronic alcoholics, there is always deficiency of thiamine becaus...
Study of acute acalculous cholecystitis as an atypical manifestation in dengue fever
Background: Dengue is a rapidly emerging global health problem. It is an arboviral disease caused by four antigenically distinct dengue viruses. Dengue epidemic occurs annually with major outbreaks in various part...
Late detection of human immunodeficiency status: An urgent need to promote early diagnosis
Background: People living with human immunodeficiency (HIV) was estimated to be 21.17 lakhs in India. Early diagnosis and early treatment with antiretroviral therapy (ART) have significant effect in reducing the morbidit...
Assessment of cardiovascular changes among chronic obstructive pulmonary disease patients at rural tertiary care center of Northern India
Background: Chronic obstructive pulmonary disease (COPD) is a complex systemic disease that has significant extrapulmonary effects along with pulmonary involvement. Cardiovascular manifestation is one of the most common...