Assessment of some inflammatory cytokines and immunologic factors in dairy cows with subclinical ketosis
Journal Title: Iranian Journal of Veterinary Science and Technology (IJVST) - Year 2021, Vol 13, Issue 2
Abstract
Altered cytokine profile and weakened immunity along with clinical or subclinical ketosis (SCK) are among the remarkable challenges around parturition. Therefore, the present study aimed to compare some inflammatory cytokines and immunologic factors between two groups of healthy and SCK cows. Serum specimens were collected from 30 clinically healthy dairy cows on the early dry period (EDP), one week before expected calving (-1w), and one week postpartum (+1W). The animals were divided into the two groups of healthy (N = 20) and SCK (N = 10) based on serum β-hydroxybutyrate cut-off of 1.2 mmol/L on +1W. The concentrations of immunoglobulin G (IgG), interleukin-4 (IL-4), IL-10, interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and haptoglobin (Hp) were measured by enzyme-linked immunosorbent assay. The data were statistically analyzed by mixed analysis of variance and independent samples t-test using the SPSS software. The findings demonstrated that the overall levels of IL-4 (p = 0.033), IL-10 (p = 0.049), TNF-α (p = 0.028), and Hp (p = 0.018) were significantly higher in the SCK group than the control group. Furthermore, the interaction of time à SCK had a significant influence on IL-4 (p = 0.028) and Hp (p = 0.022) levels. It was revealed that IL-4 (p = 0.008), IL-10 (p = 0.009), TNF-α (p = 0.01), and Hp (p = 0.002) were all significantly higher in the SCK group than the control group on +1W. In conclusion, SCK in dairy cattle might have a relationship with immunologic and inflammatory changes around calving.
Authors and Affiliations
Negar Karimi,Hesam A. Seifi,Mohammad Heydarpour,
Keywords
Related Articles
- EP ID EP722371
- DOI -
- Views 52
- Downloads 1
Prevalence of canine cutaneous neoplasms from Shiraz, Iran
The present study was conducted on 42 dogs with a histopathological diagnosis of skin neoplasia presented in the Shiraz University Veterinary Clinic from April 2012 to December 2017. All cases were reviewed, excluding th...
Serological and molecular studies on visceral leishmaniosis in stray dogs in Torbat-e-Heidareih area
Visceral leishmaniosis is an important zoonotic disease in Iran. The agent, vector and reservoir are Leishmania infantum, Phlebetomous major and dogs, respectively. Thus far, no data has been reported about the prevalenc...
A survey on the efficacy of tulathromycin in the treatment of infectious pneumonia of small ruminants in Iran
The principle aims of this study were to evaluate clinical, hematological, microbiological and macro and micro pathological effects of tulathromycin on small ruminants infectious pneumonia (IP) and to determine the side...
Histological and histochemical study of ductus deferens in Aseel and Vanaraja breeds of poultry
Aseel is an indigenous breed of poultry recognized for its majestic gait and cock fighting.Southern part of Chhattisgarh is its breeding tract. Vanaraja is a crossbreed being popularized by the Department of Animal Husba...
Morphological aspects of the brain in the Indian grey mongoose (Herpestes Edwardsii)
Mongoose is a common name for 29 to 34 species in 14 genera of the family Herpestidae which are found in vast areas of southwestern Asia, especially southern Iran. Anatomical and morphological studies of the brain...