Assessment of Some Micronutrients and Vitamins of HIV Positive Patients in South-South Nigeria
Journal Title: Journal of Clinical Medical Research - Year 2024, Vol 5, Issue 3
Abstract
Background: Human Immunodeficiency Virus (HIV) infection continues to be a serious health issue in most parts of the world, with a global prevalence of 0.7% among adults, the majority being in developing countries with limited healthcare resources. Objective: The objectives of this study was to determine the Iron, calcium, zinc, copper, Vitamins D and B12 of HIV positive subjects compared with the control, with respect to gender, age and with respect to duration of treatment. Materials: A total of fifty (50) HIV-positive subjects and fifty (50) HIV-negative subjects (control) were used in this study. Zinc, iron and calcium were evaluated using atomic absorption spectrophotometer, Vitamins D and B12 was done using ELISA, while calcium was estimated using O-cresolphthalein complexone method. The results were presented in tables and chart as mean ± standard deviation. Statistical analysis was done using one way Analysis of Variance (ANOVA) and Student’s t-test using Statistical Package for Social Sciences (SPSS) version 21.0. A p-value of <0.05 was considered significant. Results: Among the study population, 23 (46.0%) were males and 27 (54.0%) were females. With respect to age, 29 (58.0%) were aged 20 – 40 years, while 21 (42.0%) were aged 41 years and above. Based on treatment period, 28 (56.0%) were less than one year, while 22 (44.0%) were more than one year. Among the control subjects, 32 (64.0%) were males and 18 (36.0%) were females. With respect to age, 24 (48.0%) belonged to age group 20 – 40 years, while 26 (52.0%) belonged to age group 41 years and above. The results obtained showed that Calcium, zinc, copper, Iron, Vitamins B12 and D were significantly lower in HIV positive subjects compared with control (p<0.05). Calcium, Iron, Vitamins B12 and D were significantly lower (p<0.05) in age group 41 years and above in comparison with age group 20 – 40 years. Calcium, Iron, Vitamins B12 and D were significantly (p<0.05) higher in HIV positive subjects undergoing treatment for over a year compared with those undergoing treatment for less than one year. There was a significant positive correlation between Calcium and Iron (r=0.840, p=0.000), Calcium and Vitamin B12 (r=0.744, p=0.000), Calcium and Vitamin D (r=0.825, p=0.000), Iron and Vitamin B12 (r=0.743, p=0.000), Iron and Vitamin D (r=0.765, p=0.000) and Vitamin B12 and Vitamin D (r=0.562, p=0.000). Conclusion: The study concludes that the decrease in vitamins and micronutrients that accompanies HIV infection suggests a potentially important role of nutritional supplementation and good nutrition in the proper management of HIV/AIDS.
Authors and Affiliations
Omolumen LE1, Iweka FK1, Iyevhobu KO2,3*, Asibor E4, Usiobeigbe OS1, Obohwemu KO5, Okparaku SO2, Akindele IA6, Bisiriyu AH7, Irobonosen IO8, Oikerhe EG9, Ikede RE10, Animasaun OS11, Ogundana FN12, Ng’Andwe K5, Lagundoye SB13, Astaharam AJ14, Omoaka MQ1
Keywords
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- EP ID EP751281
- DOI https://doi.org/10.46889/JCMR.2024.5313
- Views 4
- Downloads 0
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