Assessment of Superoxide dismutase activity and total antioxidant capacity in adult male cigarette smokers in Nnewi metropolis, Nigeria
Journal Title: The Journal of Medical Research - Year 2017, Vol 3, Issue 1
Abstract
Background: Toxic constituents in cigarettes include carbon monoxide, benzopyrene and reactive oxygen species. Antioxidants are the body’s first line of defence against the damaging effects of free radicals and may offer protection against some harmful effects of cigarette smoking. Study design: This is a case control study. Objective: This study assessed the superoxide dismutase activity and total antioxidant capacity in adult male cigarette smokers. Method: A total of 100 subjects were recruited for this study .These comprised 50 adult male cigarette smokers and 50 adult male non-smokers as the control group. Serum superoxide dismutase activity and total antioxidant capacity were estimated using the semi- automated spectrophotometric procedure. Result: The mean serum SOD activity was significantly lower in smokers compared with the control group (P<0.05). However, no significant difference was observed in the mean serum TAC of smokers compared with the control (P>0.05). Furthermore, a negative correlation existed between the serum SOD activity of cigarette smokers and number of cigarette sticks smoked per day (r= -0.557, p=0.000).In addition, a negative relationship was observed between SOD activity and duration of smoking (r =-0.064, p=0.656). Moreover, an inverse relationship existed between total antioxidant capacity and number of cigarette sticks smoked per day (r=- 0.546, p=0.000) and between TAC and duration of smoking (r=-0.302, p=0.035). Conclusion: There is a reduction in Superoxide dismutase antioxidant enzyme activity in cigarette smokers.
Authors and Affiliations
Manafa PO, Okafor CC, Okeke CO, Chukwuma GO, Ibeh NC, Ogenyi SI, Nwene EK, Aneke JC
Keywords
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- EP ID EP442550
- DOI 10.31254/jmr.2017.3109
- Views 132
- Downloads 0
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