ASSESSMENT OF THE EFFECTS OF CANNABIS INGESTION ON LATERAL GENICULATE BODY AND SUPERIOR COLLICULUS OF WISTAR RATS
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 6
Abstract
Cannabis is a recreational drug often abused, especially by young people. It is however, classified illegal in many countries of the world. It is worth paying attention to cannabis use among young people because several behavioural and emotional aberrations have been associated with cannabis use. Such effects also vary with dosage, frequency of use and the longevity of the period of use. The current investigation considered the effects of cannabis ingestion on the lateral geniculate body and the superior colliculs in experimental animals- adult Wistar rats. These structures are vital components of the visual pathway; understanding the effects of cannabis ingestion on them might help to understand the possible effects of this psychoactive substance on vision and its pathway especially at its various levels. Twenty-four (24) adolescent Wistar rats were randomly divided into four groups of six rats each labelled A, B, C, and D. Group A animals served as the standard control; Group B animals were adminstered the low dose of cannabis [150mg/kg body weight] Group C were administered the medium dose of cannabis [250mg/kg body weight] while Group D were administered the high cannabis dose [500mg/kg body weight]. All animals were fed ad libitum on standard rat pellets throughout the duration of treatment that lasted 21 days. At the end treatment, the animals were sacrificed by cervical dislocation and the brain tissue specimens were excised, fixed in formal saline and processed using the Haematoxylin & Eosin and the Luxol Fast Blue techniques. Cannabis produced observable effects on Superior Colliculus and the Lateral Geniculate Body as reported in this study. The effects were specificically on neuronal morphology, spatial distribution of neurons and glia and neuropil integrity.
Authors and Affiliations
Owolabi J. O.
Keywords
Related Articles
- EP ID EP654990
- DOI -
- Views 155
- Downloads 0
THE EVALUATION OF TUMOR MARKERS LEVELS IN PRE AND POSTMENOPAUSAL BREAST CANCER WOMEN
Tumor markers are substances produced by the tumors or by other cells of the body in response to cancer or certain benign conditions. The cancer antigen (CA15-3) and carcinoembryonic antigen (CEA) are tumor markers that...
SIGMOID VOLVULUS A RARE CASE REPORT IN CHILDREN
Sigmoid volvulus is an uncommon problem in children and adolescents, and is rarely considered as a diagnosis in this group because it is a classic disease of the elderly. Sigmoid volvulus is rarely reported in the litera...
REVOLUTIONARY EXCELLENCE OF COMPOSITE RESINS - A REVIEW
The introduction of resin-based dental materials around the mid of the last century was a revolution in restorative dentistry. The early formulations were characterized by numerous problems like improper handling charact...
PROBIOTICS AND THEIR INDIAN AND GLOBAL VALUE: A REVIEW
Increased influx of probiotic products have been occurred in the Indian market during the last decade. However, there has been no systematic approach for evaluation of probiotics in food to ensure their safety and effica...
PROBLEMS OF MANAGEMENT OF INFERTILITY IN SUB SAHARAN AFRICA: THE EXAMPLE OF SENEGAL
Objectives: to determine the problem of the management of infertility of the couple in Senegal. Materials and methods: retrospective study carried out in the department of Gynecology and Obstetrics of the National Hospit...