Assessment of toxicity of formalin use as food preservative evidenced by cytotoxic and genotoxic effects in mice: An in vivo study
Journal Title: International Journal of Experimental Research and Review - Year 2017, Vol 12, Issue 4
Abstract
The present study was conducted to find out the deleterious effects of formalin by studying cytogenetical parameters, namely chromosome aberration (CA), mitotic indices (MI) and sperm head anomaly (SHA) in mice. Healthy mice weighing between 20-25 gms were fed with formalin at a dose 0.042mg/kg body weight to find out whether there is any toxicity induced by this chemical. Experiments were carried out at three different fixation intervals, namely 7 Days (7D), 14 Days (14D) and 21 Days (21D), maintaining suitable controls. The investigation reveals that feeding of formalin induced geno-toxicity and cyto-toxicity. This produced greater amount of CA and MI along with general increase in the SHA. Thus the increased level of geno-toxicity and cyto-toxicity could be attributed to chronic feeding of the chemical. Although our present investigation is an initial attempt to test the toxic effects of formalin, hopefully it will open up new avenues to solve critical issues yet to be discovered.
Authors and Affiliations
Tanushree Paul; Sumitava Roy; Raktim Mukherjeesub; Saikat Pramanik; Susanta Roy Karmakar
Keywords
Related Articles
- EP ID EP702178
- DOI https://doi.org/10.52756/ijerr.2017.v12.006
- Views 70
- Downloads 0
A review on phyto-remediation by aquatic macrophytes: A natural promising tool for sustainable management of ecosystem
Heavy metal pollution is a significant source of pollution in the environment. Heavy metal contamination in aquifers endangers public health and the freshwater and marine ecosystems. Traditional wastewater treatment met...
Student Research Project Report on the Basmati Patent case
RiceTec Inc, an American company, was granted a patent by the U.S. patent office in late 1997 to call the aromatic rice grown outside India ‘Basmati’ to which India objected. Since India has been one of the major exporte...
Endocrine Disruptor—A threat to the animal world
Various types of naturally occurring and artificially made chemicals cause disruption of endocrine processes among animals. They mimic biochemically with hormones and interfere with the normal signaling and activity of t...
Machine Learning-Based Gesture Recognition for Communication with the Deaf and Dumb
A deep learning model specifically designed to recognize signs in sign language is the foundation of the Sign Language Recognition system. Sign Language is a visual language used by the deaf and hard of hearing community...
Luminescent metal-organic frameworks
Metal-organic frameworks (MOFs) show a wide range of luminescent behaviours. In this review, there is a brief discussion on the origins of MOF luminosity due to various type of linkers and their special arrangement in MO...