ASSESSMENT OF VITAMIN D LEVELS IN SUDANESE PATIENTS WITH SICKLE CELL DISEASE AND ITS IMPACT ON SICKLE CELLS COMPLICATIONS-KHATOUM-2017
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 7
Abstract
Sickle cell disease SCD is a common reason urging patients of African descent to seek emergency medical care.[1] This study was done in Khartoum state in a period between March 2015 until July 2015. This study was done to assess vitamin D levels in Sudanese patients with sickle cell disease and study its impact on sickle cells complications. This study was included 200, 100 patients with SCD as case group and 100 apparently healthy subjects as a control group with matched age and gender. The results were as follow: The mean of RBC, WBCs, and platelets among case were (3.41±0.96, 10.28 ± 2.66 x103/μl, 420 ± 113.22 x 103/μl) in comparison to control (4.41±0.96, 5.72 ± 1.44 x103/μl, 222 ± 56.00 x103/μl, respectively). Hemoglobin (Hgb), PCV, MCV, MCH, MCHC in cases were (8.9 ± 1.49 g/dl, 27.12 ± 4.60%, 89.75 ± 6.64fl, 25.56 ± 2.47pg, 29.58 ± 1.00 g/dl) in comparison to control (14.11 ± 3.32g/dl, 40.45 ± 3.45%, 82.36 ± 5.82fl, 28.20 ± 2.42pg, 32.79 ± 1.21 g/dl) respectively. The serum levels of vitamin D in cases were significantly lower than in controls (14.6±3.6 vs. 27.4±4.2 ng/ml, respectively). SCD patients have lower values of Hemoglobin concentration, packed cell volume, red cell indices, but higher values of white cell count and platelets compared to controls. Vitamin D deficiency and insufficiency are predominant in SCD.
Authors and Affiliations
Tasabih A. E. Elberier
Keywords
Related Articles
- EP ID EP636185
- DOI -
- Views 131
- Downloads 0
PREVALENCE AND CHARACTERIZATION OF ENTEROCOCCAL INFECTIONS IN ENUGU STATE, NIGERIA
Enterococcus sp. considered a normal commensal of the intestine of man and other animals, is fast emerging as a pathogen, causing serious and life threatening nosocomial infections. A two year progressive study of this o...
HYPOALBUMINEMIA ON ADMISSION IS ASSOCIATED WITH INCREASED MORTALITY IN HOSPITALIZED PATIENTS PRESENTING WITH SEPSIS
Background: Hypoalbuminemia has been associated with worse clinical outcomes in a variety of conditions including kidney diseases, heart failure, trauma patients and sepsis. This study was carried out to evaluate admissi...
SEXUAL BEHAVIOUR AND CONTRACEPTIVE PRACTICES AMONG OUT- OF - SCHOOL ADOLESCENTS IN A SUBURBAN, SOUTHWESTERN, NIGERIA
Early sexual debut and high rate of risky sexual behaviour that occur in adolescent, particularly when associated with inconsistent or non-use of contraception, predispose them to serious short and long term health conse...
ASSOCIATION BETWEEN PANCREATIC CANCER AND DEPRESSION
Background: Pancreatic cancer has very poor prognosis. Also, the surgical intervention is very high as compared to other cancers. This is associated with high depression and anxiety in the patients. In this study, we tri...
VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) METHOD FOR DETERMINATION OF TRIMETAZIDINE IN PHARMACEUTICAL DOSAGE FORMS
A stability-indicating HPLC method was validated for the determination trimetazidine in tablet dosage form. The chromatographic conditions comprised of a 250 X 4.6 mm column containing 5-μm; packing L1 (C18), with a mobi...