Assessment of Vitamin D Status and Growth Parameters in Thalassemia Major Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Background: Vitamin D deficiency and insufficiency has been frequently reported in thalassemic patients in many countries despite the presence of good sunshine. Adequate circulating level of vitamin D is essential for optimal skeletal growth and reducing fracture risk. Objective: To assess Vitamin D, Calcium, Phosphorus status and growth parameters in thalassemia major patients Methodology: This study, a hospital based case control study was conducted from January 2016 to December 2016 in Department of Paediatrics and Neonatology, Rajendra Institute of Medical Sciences, Ranchi. In this study, 60 patients of beta thalassemia major (aged from 8 months to 12 years) were compared with 60 sex and age matched children serving as control group. Anthropometric measurement, serum level of calcium, phosphorus and vitamin D (25 hydroxy cholecalciferol) were estimated for all patients & controls. Results: 25 hydroxy vitamin D deficiency was present in 82% of the patients and in 47% of the controls. Difference in mean vitamin D levels between cases and controls was statistically significant (p<0.05). Weight and body mass index were also significantly lower (p<0.05) in cases. Conclusion: Thalassemia is associated with increased prevalence of 25 hydroxy vitamin D deficiency which may be responsible for poor growth and quality of life in these children. Monitoring and maintaining normal serum level of 25-OH vitamin D through oral intake of vitamin D and early correction of Vitamin D deficiency by oral or parenteral use of vitamin D may significantly improve bone mineral deposition and improved quality of life in these children. Keywords: Thalassemia, 25 hydroxy vitamin D, Calcium, Growth
Authors and Affiliations
Dr. M. R. Akhouri, Dr. Dipti Neha
Keywords
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