Assessment of Vitamin D Status In Patients With Essential Hypertension
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 5
Abstract
<strong>Background: </strong>There is close relationship between Vit D deficiency and hypertension. It was found that Vit D is potent inhibitor of Renin Aldosterone Angiotensin System (RAAS) which is the main mechanism responsible for development of hypertension.<strong> Aim of The Work: </strong>To assess the role of vitamin D deficiency in the development of essential hypertension and aggravation of its vascular complications.<strong> Subjects and Methods: </strong>This study was conducted on 80 individuals. Individuals were divided into two groups: Group 1: comprising 60 patients with essential hypertension. Group 2: comprising 20 healthy individuals. All individuals included in the study were submitted to: Complete history and physical examinations to evaluate exclusion criteria. Liver and renal function tests, fasting and PP blood glucose, CBC, lipid profile, serum vitamin D (25hydroxycholecalciferol), serum Ca & Ph. Doppler study on carotid artery to assess vascular complications and Echocardiography to assess ventricular mass was done.<strong> Results: </strong>There was statistically significant decrease (p value <0.05) in vitamin D in patients group in comparison to control group. There was highly statistically significant increase (p value <0.001) in intimal thickness and left ventricular mass in patients with low vitamin D level in comparison to patients with normal vitamin D level. In the patient group, 6 patients (10%) were suffering from vitamin D deficiency while 30 (50%) were suffered from vitamin D insufficiency while 24 (35%) show normal levels of vitamin D. Interestingly, intimal thickness and ventricular mass were significantly higher in patients with essential hypertension with low vitamin D than those with normal vitamin D levels. <strong>Conclusions:</strong> Vitamin D deficiency occurs in the majority of essential hypertension patients and therefore decreased serum vitamin D levels is considered an additional risk factor for cardiovascular morbidity and mortality.
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584159
- DOI 10.12816/ejhm.2018.9496
- Views 108
- Downloads 0
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