Abstract

The Commiphoramukul (guggul gum) is extracted from the stem of C. mukul. It is important for various medicinal and pharmacological applications used in various formulation of ayurveda. Guggul gum is pharmacologically active in controlling rheumatoid arthritis, obesity and peptic ulcers. The pharmacological and clinical studies on its crude drug constituents and various extractives have revealed its significant hypocholestermic, hypolipidimic, antiinflammatory, antirheumatic and antifertility activities The potential antibacterial efficacy of guggul gum was checked against four Gram-positive and four Gram-negative bacterial strains Streptococcus agalactiae,Staphylococcusaureus.Escherichia Coli and Pseudomonasaeruginosa. The antibacterial activity was assessed by agar well diffusion and two fold serial broth dilution methods. Gram-positive bacterial strains were found to be the most susceptible organisms compare to Gram-negative towards guggul gum extracts. In traditional medicine and Ayurveda plants have been known to relieve various diseases. The medicinal properties of plants mainly depend on secondary metabolites that are playing key role I relive from various diseases. In the present study ethyl acetate and methanol extract of C.mukulwere screened for the presence of phytochemicals by standard procedures. Phytochemical analysis revealed that the presence or absence of alkaloids, flavonoids, proteins, quinons, reducing sugars, saponin, and phenolics. Antimicrobial activity was observed in C.mukul against E.coli,S.agalactiae andS. aureuswhich may be due to different bioactive compounds present in the plant of C.mukul. In general very less or no activity is observed against P. aeruginosa

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