Associated Factors of The Metastatic Lymph Node Involvement in Colorectal Cancers
Journal Title: Hippocrates Medical Journal - Year 2022, Vol 2, Issue 3
Abstract
Introduction : The number of metastatic lymph nodes is the most important prognostic factor that affects disease-free and overall survival in many cancer types. In the study, the factors associated with metastatic lymph node involvement were investigated in colorectal cancers. Materials and Methods : A total of 192 colorectal cancer patients who underwent curative surgery between 2016 and 2021 were included in the study. Patients who had a diagnosis other than adenocarcinoma, whose data could not be obtained and emergency cases were excluded from the study. According to these 4 groups, patients were compared in terms of parameters such as age, gender, tumor stage, histopathological grade, tumor localization, lymphovascular invasion, perineural invasion, neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, monocyte count, and the total number of lymph nodes. Results : Among the 192 patients included in the study, 75 (39.06%) were female, and 117 (60.94%) were male. The mean age was 67 (23: 89), and the mean follow-up time was 20 (2: 63) months. According to metastatic lymph node involvement, the number of N0, N1, N2a, and N2b patients was 101, 57, 20, 14, respectively. No significant relations were detected between metastatic lymph node involvement and age, gender, neutrophil/lymphocyte ratio, and lymphocyte/monocyte ratio. As the number of metastatic lymph nodes increased, survival rates decreased (p=0.002). Histopathological grade, T stage, lymphovascular invasion, perineural invasion, increased tumor diameter, the total number of lymph nodes removed and increased monocytes were found to be significantly associated with metastatic lymph node involvement (p<0,001; p<0,001; p<0,001; p<0,001; p=0,036; p<0,001; p=0,035). Conclusion : In the present study, except for standard prognostic factors, increased monocytes were associated with lymph node enlargement. High monocyte count in colorectal cancer patients undergoing surgical treatment requires careful evaluation in terms of lymph node involvement.
Authors and Affiliations
Suat BENEK, Sami AÇAR
Keywords
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- EP ID EP711336
- DOI 10.29228/HMJ.22
- Views 67
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