ASSOCIATION BETWEEN APOLIPOPROTEIN A5-1131T>C (RS662799) GENE POLYMORPHISM AND LIPID PROFILE IN ISCHEMIC HEART DISEASES
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2019, Vol 5, Issue 4
Abstract
Background: the most common type of Ischemic Heart Diseases, includes :stable and un stable angina and myocardial infarction, a chronic condition that narrows arteries by building fat-filled bulges in the arterial walls. Apolipoprotein A5 Gen polymorphisms On the genetic side that associated with Ischemic Heart Diseases. Aim: To assess the association of the Apolipoprotein A5-1131T>C (rs662799) gene with the Ischemic Heart Diseases in the genral population, and verify the relationship of the investigated SNPs with the metabolic changes related to IHD, in particular, serum lipid profile. Methods: A case control study was performed at which 100 patients with Ischemic Heart Diseases and 100 healthy individuals. Genotyping for SNP 1131T>C (rs662799) in the Apolipoprotein A5 gene was performed by the Genotyping of polymerase chain reaction- Amplification Refractory Mutation System (PCR-ARMS) method. Lipid profile (HDL,LDL,TAG,VLDL) were measured by enzymatic methods. Results: The genotype and allele frequencies of APOA5 gene polymorphism in IHD and control persons were examined under the co-dominant, dominant and recessive models with the use of multinominal logistic regression analysis. Genotype frequencies of rs662799 were consistent with Hardy-Weinberg equilibrium in both IHD and Control. The power of this study to detect a significant difference at level of 0.05 was 91.2%. The results shown that APOA5 gene polymorphism rs662799 (homozygous CC and heterozygous TC genotype) was significantly associated with IHD patients and the frequency of C allele was higher in IHD patients. There is significant increases in the level of triglyceride (P=0.001), VLDL (P=0.001), BMI(P=0.001) and a significant decrease in the level of cholesterol (P=0.03), Low density lipoproteins (P=0.2) in the group of patients with the CT+CC genotypes when they were compared with those of the TT genotype. Discussion: The results shown that APOA5-1131T>C (rs662799) gene polymorphism (homozygous CC and heterozygous CT genotype) was significantly associated with IHD subject. Conclusion: The -1131T>C (rs662799) SNP of APOA5 gene is associated with Ischemic Heart Diseases. in the population of Kerbala. The C allele is seemed to increase serum lipid concentrations so it could be considered as an atherosclerotic parameter.
Authors and Affiliations
Dr. Noor Kitab Al-Hasnawi
Keywords
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