ASSOCIATION BETWEEN CHRONIC AUTOIMMUNE THYROIDITIS AND NESFATIN-1 LEVELS
Journal Title: Kocatepe Medical Journal - Year 2022, Vol 23, Issue 3
Abstract
OBJECTIVE: The aim of this study was to evaluate relationship between nesfatin-1 levels and thyroid autoimmunity in cases with chronic thyroiditis. MATERIAL AND METHODS: A total of 49 consecutive premenopausal women with Hashimoto’s thyroiditis and, age and body mass index (BMI)-matched 23 healthy female subjects were included in this cross-sectional comparative study. Levels of nesfatin-1, fasting and postprandial blood glucose, hemoglobin A1c (HbA1c), fasting insulin, cholesterol, free thyroxine (FT4), free triiodothyronine (FT3), thyrotropin (TSH), anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (anti-TG) were obtained for all cases. Additionally homeostatic model assessment for insulin resistance (HOMA-IR) and BMI was calculated and waist-to-hip ratio (WHR) was measured for each case. RESULTS: The mean age of the group with Hashimoto’s thyroiditis was 35.5±8.1 years and of the healthy controls was 33.2±7.1 years old (p=0.324). BMI and WHR were similar between the groups (p=0.239 and p=0.317). TSH, anti-TPO and anti-TG levels were significantly higher in cases with Hashimoto’s thyroiditis (p=0.023, p<0.001 and p<0.001). Triglyceride levels were higher in the patients with Hashimoto’s thyroiditis at the limit of statistical significance (p=0.05). Nesfatin levels were not different statistically in between two groups [0.4 (0.39-0.43) , 0.39 (0.39-0.39) ng/ml;p=0.329]. CONCLUSIONS: Alterations in thyroid hormones or autoimmunity in chronic autoimmune thyroditis may not alter nesfatin-1 levels. Different mechanisms, other than nesfatin-1, may be responsible for changes in satiety and energy expenditure in Hashimoto’s thyroiditis.
Authors and Affiliations
Fatma Dilek DELAL, Mutlu NİYAZOĞLU, Esra HATİPOĞLU, Esranur ADEMOĞLU, Fatma Gül AKSOY, Halime ÜNVER, Yalçın ARAL
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- EP ID EP706874
- DOI https://doi.org/10.18229/kocatepetip.885143
- Views 85
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