Association between Coronary Artery Ectasia and Neutrophil: Lymphocyte Ratio
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 5
Abstract
ABSTRACT Introduction: Inflammation, endothelial dysfunction and atherosclerosis are associated with the aetiopathogenesis of Coronary Artery Ectasia (CAE). The Neutrophil to Lymphocyte (N/L) ratio has emerged as a new inflammation marker for cardiovascular disease. Aim: To assess the association between the CAE and the N/L ratio. Materials and Methods: A total of 179 patients with isolated CAE, Obstructive Coronary Artery Disease (O-CAD) and normal coronaries (controls) were enrolled. Clinical characteristics and pattern of ectatic involvement were seen. N/L ratio values were compared between the three groups using Analysis of Variance (ANOVA). Results: Study findings showed that the patients with isolated CAE had significantly elevated N/L ratio values compared to O-CAD and control groups (2.63±0.36 vs. 2.20±0.27, p<0.001 and vs. 1.93±0.24, p<0.001) respectively. Right Coronary Artery (RCA) was the most commonly involved ectatic artery (64.2%). Single vessel ectasia (44.6%) and Type IV (32.1%) were the most common pattern of involvement. Conclusion: In present study, we found that patients with isolated CAE had a significantly higher WBC count and N/L ratio than patients with O-CAD and control groups. This finding suggests that severe inflammatory process could be involved in the development of CAE as compared to CAD.
Authors and Affiliations
Gaurav Kavi, Amit Malviya, Animesh Mishra, Sakshi Sharma, Tony Ete, Rinchin Dorjee Megeji, Swapan Kumar Saha, Manish Kapoor
Keywords
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- EP ID EP522960
- DOI 10.7860/JCDR/2018/31844.11512
- Views 75
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