Association between different degrees of hypothyroidism and serum lipids
Journal Title: Internet Journal of Medical Update - Year 2012, Vol 7, Issue 2
Abstract
The association between overt hypothyroidism (OH) and altered lipid profile is well known, however the significance of dyslipidemia in subclinical hypothyroidism (SCH) remain controversial. Therefore, this study was conducted to determine any association between lipid profile and different degrees of thyroid dysfunction. Thyroid and lipid profile parameters were analysed in 58 patients with overt (TSH ≥ 10.0 µIU/L and/or abnormally low fT4 and fT3 levels) and 87 patients with subclinical hypothyroidism (TSH 6.0-9.9 µIU/L with normal fT4 and fT3 levels) in this case-control study. These were compared with 100 age- and sex-matched euthyroid controls. It was found that only mean serum level of total cholesterol in patients with SCH was significantly high from that in controls (p=0.045). Other lipid parameters did not show any statistical significance. Whereas patients with OH had statistically significant higher levels of total cholesterol (p<0.001), triglyceride (p<0.05), LDL-C (p<0.001) and VLDL-C (p<0.05). There was also an increase in HDL-C in both SCH and OH group though not significant statistically. In conclusion, lipid profile is not much deranged in SCH whereas OH is a major cause of secondary dyslipidemia which may lead to increased risk of coronary artery disease. Therefore, thyroid hormone replacement would be most beneficial in patients with OH instead of SCH. However, patients with SCH should be monitored for deterioration of thyroid function and dyslipidemia at regular intervals.
Authors and Affiliations
Vandana Saini, Amita Yadav, Sarika Arora, Ritu Singh, Jayashree Bhattacharjee
Keywords
Related Articles
- EP ID EP130123
- DOI -
- Views 72
- Downloads 0
NANOPARTICLES IN NUCLEAR IMAGING
The present review article summarizes the current state radiolabeled nanoparticles for molecular imaging applications mainly targeting cancer. Due to their enormous flexibility, and versatility the radiolabeled nanoparti...
‘Radiopath’- an assimilation of radiology and pathology: a need of the day
Selfmonitoring of blood glucose practices by people living with diabetes who use their personal glucometers in Port Harcourt, Niger Delta Region, Nigeria
Self-monitoring of blood glucose (SMBG) assists persons living with diabetes with the day-to-day behavioral and therapeutic adjustments to their diabetes care. It is a cheaper and more available alternative to glycated h...
An E-mail Service in a Military Adolescent Medicine Clinic: will teens use it and what for?
The goal of this study was to determine utilization patterns of an Adolescent Medicine Clinic e-mail service. An e-mail service was offered to 6134 patients presenting for care to a military Adolescent Medicine Clinic in...
ACTIVATION OF NF-κ B SIGNALLING PATHWAY BY INFLAMMATORY REGULATORS AND ASSOCIATED DRUG DISCOVERING
Intracellular signalling transduction plays a pivotal role in cell activation, and the regulation of gene transcription needs the involvement of series of nuclear factors. Nuclear transcription factor- kappa B, one of th...