Association between different degrees of hypothyroidism and serum lipids
Journal Title: Internet Journal of Medical Update - Year 2012, Vol 7, Issue 2
Abstract
The association between overt hypothyroidism (OH) and altered lipid profile is well known, however the significance of dyslipidemia in subclinical hypothyroidism (SCH) remain controversial. Therefore, this study was conducted to determine any association between lipid profile and different degrees of thyroid dysfunction. Thyroid and lipid profile parameters were analysed in 58 patients with overt (TSH ≥ 10.0 µIU/L and/or abnormally low fT4 and fT3 levels) and 87 patients with subclinical hypothyroidism (TSH 6.0-9.9 µIU/L with normal fT4 and fT3 levels) in this case-control study. These were compared with 100 age- and sex-matched euthyroid controls. It was found that only mean serum level of total cholesterol in patients with SCH was significantly high from that in controls (p=0.045). Other lipid parameters did not show any statistical significance. Whereas patients with OH had statistically significant higher levels of total cholesterol (p<0.001), triglyceride (p<0.05), LDL-C (p<0.001) and VLDL-C (p<0.05). There was also an increase in HDL-C in both SCH and OH group though not significant statistically. In conclusion, lipid profile is not much deranged in SCH whereas OH is a major cause of secondary dyslipidemia which may lead to increased risk of coronary artery disease. Therefore, thyroid hormone replacement would be most beneficial in patients with OH instead of SCH. However, patients with SCH should be monitored for deterioration of thyroid function and dyslipidemia at regular intervals.
Authors and Affiliations
Vandana Saini, Amita Yadav, Sarika Arora, Ritu Singh, Jayashree Bhattacharjee
Keywords
Related Articles
- EP ID EP130123
- DOI -
- Views 86
- Downloads 0
Evaluation of Homocysteine, Lipoprotein(a) and Endothelin as diagnostic markers of Coronary Artery Disease in Indian population
Indians have been reported to have high prevalence rates of coronary artery disease (CAD) even in the absence of traditional risk factors. The objective of this study was to assess the role of endothelin, lipoprotein(a),...
Association of Intronic Single Nucleotide Polymorphism (SNP) of CALM 1 gene with Osteoarthritis of the Knee in Indian Population: A Case-control Study
Osteoarthritis knee is one of the most prevalent disorders in the Indian subcontinent. The wide prevalence and varying features makes it a disease of disguise. Multiple etiological factors have been described. The most r...
Effects of co-treatment of Rauwolfia vomitoria and Gongronema latifolium on neurobehaviour and the neurohistology of the cerebral cortex in mice
Rauwolfia vomitoria and Gongronema latifolium are medicinal plants with antioxidant, antidiabetic and analgesic properties among others. R. vomitoria is reported to possess adverse neural effects, which G. latifolium has...
PROTEOMICS: AN EVOLVING TECHNOLOGY IN LABORATORY MEDICINE
The rapid developments in both genomics and proteomics will allow scientists to define the molecular pathways in normal and diseased cells. With these models, researchers will have the ability to predict previously unkno...
Study on the attitude of “Tomorrow’s Doctors” towards mental illness: A cross-sectional study
Different studies show different attitudes towards mental illness among medical students. This study was initiated to explore the attitude towards mental illness among medical students in a medical college of Manipur. A...